Divergent electrolysis for the controllable coupling of thiols with 1,2-dichloroethane: a mild approach to sulfide and sulfoxide

Abstract

Organosulfurs are important commodity chemicals and indispensable synthetic intermediates in modern chemistry that traditionally synthesized using metal catalysts, oxidants or strong bases, which caused numerous issues of environment pollutions. The...

Catalyst-free electrosynthesis of benzothiophenes from 2-alkenylaryl disulfides

“…Furthermore, according to the previous reports, electrolysis of 1,2-dichloroethane affords HCl and chloroethane via sequential cathodic reduction and anodic oxidation. 16 In this regard, 0.1 M solution of Et 4 NOTs in DCE was pre-electrolyzed under the standard reaction conditions for 2.5 h. Next, electrolysis was stopped, and disulfide 1a was added and stirred for an additional 5 h. It turned out that the reaction did not proceed and benzothiophene 2a was not found (Fig. 3d).…”

Electrosynthesis of amino acids from biomass-derived α-hydroxyl acids

“…Compared to all the reported processes, electrosynthesis has been regarded as a sustainable and efficient method, as it does not require any external oxidants/reductants and is usually carried out under ambient conditions. [18][19][20] Indeed, electrochemical reductive amination has been reported for the synthesis of amino acids from α-keto acids in a flow electrolyzer when NH 2 OH was employed as the nitrogen source. 21 In this case, the counter reaction is water oxidation and IrO 2 was used as the anode to drive the oxygen evolution reaction (OER).…”

“…Compared to all the reported processes, electrosynthesis has been regarded as a sustainable and efficient method, as it does not require any external oxidants/reductants and is usually carried out under ambient conditions. 18–20…”

One-pot thiol-free synthetic approach to sulfides, and sulfoxides selectively

“…A common strategy to prepare organosulfur compounds, especially sulphides, is to use thiols as starting materials. 9 The synthesis of sulfides from thiols is promoted by the ease of their availability and high reactivity. 10 However, thiols often restrict the direct synthesis of desired sulfides due to inherent disadvantages such as awfully irritating smell and side effects concerning health.…”

“… 15 Afterwards, the thiols are transformed further to desired unsymmetrical sulfides. 9 We questioned whether an easier, shorter, and odorless protocol can be realized for the preparation of sulfides. Gratifyingly, here we present a synthetic strategy that combines the aforementioned three steps in one-pot.…”