Divergent incorporation of dietary <i>trans</i> fatty acids in different serum lipid fractions

Vidgren, Helvi M.; Louheranta, Anne; Ågren, Jyrki; Schwab, Ursula; Uusitupa, Matti

doi:10.1007/s11745-998-0292-9

Cited by 34 publications

(30 citation statements)

References 29 publications

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“…From this difference arise their different physiological effects: trans isomers are similar to saturated fatty acids, while cis isomers have more beneficial effects. As cis and trans fatty acids use the same enzymes during their metabolism, several studies have indicated, that trans fatty acids may disturb the metabolism of the physiologically important n-3 and n-6 fatty acids (Szabó et al, , 2010aVidgren et al, 1998). Fig.…”

Section: Biochemistry Of Fatty Acidsmentioning

confidence: 99%

Fatty Acid Supply in Pregnant Women with Type 1 Diabetes Mellitus

Szabó¹,

Marosvölgyi²,

Décsi³

2011

Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments

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Section: Biochemistry Of Fatty Acidsmentioning

confidence: 99%

Fatty Acid Supply in Pregnant Women with Type 1 Diabetes Mellitus

Szabó¹,

Marosvölgyi²,

Décsi³

2011

Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments

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“…Biological markers of fat intake offer an alternative to assessing TFA exposure because tissue fatty acid composition reflects actual rather than reported intake, thus avoiding the particular problems of quantifying 'hidden' fats or the well-established underreporting of fat intake (Beaton et al, 1979;Bingham, 1987;Bingham et al, 1994). Biomarkers of TFA intake are particularly good (Vidgren et al, 1998;Lichtenstein et al, 2003) because there is negligible endogenous synthesis of TFAs and there is a dose-response relation with dietary intake (Mensink and Hornstra, 1995). There are examples of biomarkers being used to monitor changes in population intakes of TFAs over time (Innis et al, 1999;Clifton et al, 2004;Colon-Ramos et al, 2006).…”

Section: Monitoring Compliancementioning

confidence: 99%

Feasibility of recommending certain replacement or alternative fats

Skeaff

2009

Eur J Clin Nutr

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Expert groups and public health authorities recommend that trans-fatty acid (TFA) intakes from industrially produced partially hydrogenated vegetable oils (PHVOs) should be less than 1% of total energy intake. The starting point for any regulatory or nonregulatory response to this recommendation is to assess the extent of the problem by determining where in the food supply TFAs are found and the amounts consumed in the population. Unfortunately, this is a particularly difficult task using traditional methods of dietary assessment inasmuch as food composition databases with TFA data are either nonexistent or incomplete in most countries. Current evidence on estimates of intake suggests there is high variability in TFA intakes and their food sources between countries. The ubiquitous presence of PHVOs in the global food supply in bakery products, deep-fried foods, snack foods, confectionery products and table spreads attests to their commercial value and convenience. However, their common use is more the result of historical convenience from an industry infrastructure developed over 50 years based on efficient, costeffective hydrogenation of vegetable oils rather than any inherent sensory or physical superiority of the hydrogenated fats over purpose-made zero-trans fats and oils. Current global supply of appropriate zero-trans replacement fats high in cis-unsaturated fatty acids is insufficient to meet the demand if all PHVOs in the food supply were replaced. Regulatory action needs to be coordinated with supply to maximize the opportunity for health gains by replacing partially hydrogenated fats with purposeready zero-trans vegetable oils low in saturates and high in cis-unsaturates rather than animal fats and tropical oils high in saturated fatty acids.

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“…Beyond cardiovascular disease risk, another concern about trans fatty acids is theoretical at present. In both animal and human studies, dietary trans fatty acids have been determined to be digested, absorbed and incorporated into serum triglycerides, cholesterol esters, phospholipids, lipoproteins and adipose tissue, 10, [30][31][32] or platelets, 33) in the same way as natural cis isomers.…”

Section: Other Risks Of Trans Fatty Acidsmentioning

confidence: 99%