2013
DOI: 10.1152/ajpregu.00567.2012
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Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues

Abstract: Perivascular adipose tissue (PVAT) is implicated as a source of proatherogenic cytokines. Phenotypic differences in local PVAT depots may contribute to differences in disease susceptibility among arteries and even regions within an artery. It has been proposed that PVAT around the abdominal and thoracic aorta shares characteristics of white and brown adipose tissue (BAT), respectively; however, a detailed comparison of the phenotype of these PVAT depots has not been performed. Using young and older adult rats,… Show more

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Cited by 146 publications
(147 citation statements)
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References 48 publications
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“…As shown, WR and DR had less lipid deposition in brown and periaortic AT, as well as decreased adipocyte size in white AT. Consistent with our previous report (42), a clear structural similarity between thoracic perivascular AT and interscapular brown AT was noted. As depicted in Fig.…”
Section: Resultssupporting
confidence: 92%
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“…As shown, WR and DR had less lipid deposition in brown and periaortic AT, as well as decreased adipocyte size in white AT. Consistent with our previous report (42), a clear structural similarity between thoracic perivascular AT and interscapular brown AT was noted. As depicted in Fig.…”
Section: Resultssupporting
confidence: 92%
“…In addition, plasma and periaortic AT-conditioned medium samples were assayed for concentrations of leptin, MCP-1, TNF-␣, and IL-6 using a multiplex cytokine assay (Millipore Milliplex, cat no. RCYTOMAG-80K; Billerica, MA) on a MAGPIX instrument (Luminex Technologies; Luminex, Austin, TX), according to the manufacturer's instructions (25,42).…”
Section: Animalsmentioning
confidence: 99%
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“…Sections were evaluated via an Olympus BX60 photomicroscope (Olympus, Melville, NY), and images were taken at ϫ10 (AT) or ϫ20 (liver) magnification via SPOT Insight digital camera (Diagnostic Instruments, Sterling Heights, MI). Adipocyte size was calculated based on 100 adipocytes/animal from three, ϫ10 fields of view, as performed previously (28). In brief, cross-sectional areas of the adipocytes were obtained from perimeter tracings using ImageJ software [National Institutes of Health (NIH) public domain; NIH, Bethesda, MD].…”
Section: Methodsmentioning
confidence: 99%