Divergent Roles of Antiself Antibodies during Infection

Rivera-Correa, Juan; Rodrı́guez, Ana

doi:10.1016/j.it.2018.04.003

Cited by 45 publications

(54 citation statements)

References 61 publications

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“…Recent evidence suggests that any infection can trigger immune dysregulation, loss of immune tolerance, and development of immune‐mediated disease in an individual patient with a genetic, epigenetic, or susceptible microenvironmental milieu at the time of infection . However, certain organisms may cause specific immune‐mediated diseases.…”

Section: Putative Trigger Factorsmentioning

confidence: 99%

ACVIM consensus statement on the diagnosis of immune‐mediated hemolytic anemia in dogs and cats

Garden

Kidd

Mexas

et al. 2019

Veterinary Internal Medicne

132

196

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Immune‐mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs in cats, although less commonly. IMHA is considered secondary when it can be attributed to an underlying disease, and as primary (idiopathic) if no cause is found. Eliminating diseases that cause IMHA may attenuate or stop immune‐mediated erythrocyte destruction, and adverse consequences of long‐term immunosuppressive treatment can be avoided. Infections, cancer, drugs, vaccines, and inflammatory processes may be underlying causes of IMHA. Evidence for these comorbidities has not been systematically evaluated, rendering evidence‐based decisions difficult. We identified and extracted data from studies published in the veterinary literature and developed a novel tool for evaluation of evidence quality, using it to assess study design, diagnostic criteria for IMHA, comorbidities, and causality. Succinct evidence summary statements were written, along with screening recommendations. Statements were refined by conducting 3 iterations of Delphi review with panel and task force members. Commentary was solicited from several professional bodies to maximize clinical applicability before the recommendations were submitted. The resulting document is intended to provide clinical guidelines for diagnosis of, and underlying disease screening for, IMHA in dogs and cats. These should be implemented with consideration of animal, owner, and geographical factors.

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Section: Putative Trigger Factorsmentioning

confidence: 99%

ACVIM consensus statement on the diagnosis of immune‐mediated hemolytic anemia in dogs and cats

Garden

Kidd

Mexas

et al. 2019

Veterinary Internal Medicne

132

196

View full text Add to dashboard Cite

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“…The mechanisms underlying the loss of uninfected erythrocytes are not clear yet, but malaria-induced anemia was recently related to autoimmune responses in patients [ 10 ]. Malaria, as other highly inflammatory infectious diseases, induces a strong autoimmune response characterized by the generation of anti-self antibodies with different specificities [ 11 – 13 ]. Studies in mice models of malaria showed that antibodies recognizing the lipid phosphatidylserine (PS) exposed on the surface of uninfected erythrocytes promote their clearance contributing to anemia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections

Rivera-Correa¹,

Yasnot²,

Tovar³

et al. 2020

PLoS Negl Trop Dis

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Malaria caused by Plasmodium vivax is a highly prevalent infection worldwide , that was previously considered mild, but complications such as anemia have been highly reported in the past years. In mice models of malaria, anti-phosphatidylserine (anti-PS) autoantibodies, produced by atypical B-cells, bind to uninfected erythrocytes and contribute to anemia. In human patients with P. falciparum malaria, the levels of anti-PS, atypical B-cells and anemia are strongly correlated to each other. In this study, we focused on assessing the relationship between autoantibodies, different B-cell populations and hemoglobin levels in two different cohorts of P. vivax patients from Colombia, South America. In a first longitudinal cohort, our results show a strong inverse correlation between different IgG autoantibodies tested (anti-PS, anti-DNA and anti-erythrocyte) and atypical memory B-cells (atMBCs) with hemoglobin in both P. vivax and P. falciparum patients over time. In a second cross-sectional cohort, we observed a stronger relation between hemoglobin levels, atMBCs and autoantibodies in complicated P. vivax patients compared to uncomplicated ones. Altogether, these data constitute the first evidence of autoimmunity associating with anemia and complicated P. vivax infections, suggesting a role for its etiology through the expansion of autoantibody-secreting atMBCs.

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“…Some pathogens have been reported to be associated with the pathogenesis of autoimmune disorders 16,17 . These infectious agents trigger autoimmune diseases via various The proposed mechanisms include molecular mimicry, which antibodies against bacterial antigens that are similar to the host 19 . For example, autoimmune diseases such as Crohn's disease, ulcerative colitis, and sarcoidosis are commonly found in Mycobacterium tuberculosis patients 20 .…”

Section: Discussionmentioning

confidence: 99%

A cohort study: The Association Between Autoimmune Disorders and Leptospirosis

Teh

You

et al. 2020

Sci Rep

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& cheng-Yoong pang 6,7,8* there are limited studies on the association between systemic autoimmune rheumatic diseases (SARDs) and leptospirosis. Therefore, this study aims to identify the effects of leptospirosis on the risks of developing SARDs with a nationwide retrospective cohort study. Patients with leptospirosis who did not have a diagnosis of SARDs before the index date were enrolled from the Taiwan National Health Insurance Research Database between 2000 and 2010, as the leptospirosis cohort. For each patient with leptospirosis, one control without a history of leptospirosis and SARDs was randomly selected (non-leptospirosis cohort). Cox proportional hazards regression models were used to analyze the risk of SARDs according to sex, age, and comorbidities. Among the 23 million people in the cohort, 3,393 patients with leptospirosis (68.91% men, mean age 52.65 years) and 33,930 controls were followed for 18,778 and 232,999 person-years, respectively. The incidence of SARDs was higher in the leptospirosis cohort than in the non-leptospirosis cohort (1.38 vs 0.33 per 1000 person-years), with a hazard ratio (HR) of 4.42 (95% confidence interval [CI] = 2.82-6.92). The risk of developing SARDs was highest for leptospirosis patients aged ≥65 years (HR = 2.81% CI = 1.07-7.36) compared with patients aged ≤39 years. Patients with leptospirosis have a 4.42-fold higher risk of SARDs than that in the general population. Further research is warranted to investigate the mechanism underlying this association. Leptospirosis is a zoonotic disease caused by pathogenic spirochetes, genus Leptospira. Leptospirosis can be found globally, with a higher incidence in tropical and subtropical regions 1. The pathogen can enter the host through wounds in the skin, the conjunctiva, and mucous membranes. By direct contact with the body fluids from the infected domestic and sylvatic animals, humans may also be infected. Once infected, patients can either be asymptomatic or manifested as an acute febrile illness, with fever, chills, arthralgia, headache, and severe myalgia. Occasionally, it can cause severe disease leading to multiorgan dysfunction and even death 2. The nonspecific initial presentation and lack of a reliable point-of-care screening test make this disease a diagnostic challenge 3,4. Autoimmune diseases are conditions that are triggered by the immune system initiating an attack on self-molecules due to the worsening of immunologic tolerance to auto-reactive immune cells 5. Both environmental and genetic are significant contributors to the pathogenesis of autoimmune diseases 6. Autoimmune diseases can either be systemic, organ-specific or localized to specific tissue or region depending on the clinicopathology of each condition. Systemic autoimmune rheumatic diseases (SARDs) are a collective term for more than 80 systemic autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SS), Sjogren's syndrome, polymyositis, dermatomyositis. Female are inordinately affecte...

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Divergent Roles of Antiself Antibodies during Infection

Cited by 45 publications

References 61 publications

ACVIM consensus statement on the diagnosis of immune‐mediated hemolytic anemia in dogs and cats

ACVIM consensus statement on the diagnosis of immune‐mediated hemolytic anemia in dogs and cats

Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections

A cohort study: The Association Between Autoimmune Disorders and Leptospirosis

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