Diverging effects of cholestyramine on apolipoprotein B and lipoprotein Lp(a)

Vessby, Bengt; Kostner, Gert M.; Lithell, Hans; Thomis, J.

doi:10.1016/0021-9150(82)90053-3

Cited by 149 publications

(30 citation statements)

References 22 publications

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“…(31,44,(47)(48)(49). In fact, treatment with drugs such as cholestyramine and cholesterol synthesis inhibitors, which are known to induce hepatic LDL receptor expression in man (50, 51), do not reduce, and sometimes may even increase, Lp (a) levels (12,(28)(29)(30). However, recent studies using a drastic induction of human LDL receptors in transgenic mice have demonstrated the possibility for an enhanced clearance ofLp (a) particles during stimulation of the LDL receptor pathway (31).…”

Section: Discussionmentioning

confidence: 99%

“…The role ofthe LDL receptor in the clearance of Lp (a) is still debated, however. Thus, no reduction in Lp (a) levels has been observed during treatment with drugs known to stimulate the elimination of LDL from plasma via induction ofLDL receptors, such as cholestyramine and cholesterol synthesis inhibitors (12,(28)(29)(30). On the other hand, overexpression ofthe human LDL receptor in transgenic mice clearly increases the plasma clearance of Lp (a) (31).…”

Section: Introductionmentioning

confidence: 99%

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Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.

Henriksson¹,

Angelin²,

Berglund³

1992

J. Clin. Invest.

150

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Serum concentrations of lipoprotein (a) [Lp (a)j were determined in two groups of elderly males suffering from prostatic carcinoma, who were randomized to treatment with estrogen (n = 15) or orchidectomy (n = 16). Estrogen was given as oral ethinylestradiol, 150 ,ug daily, combined with intramuscular polyestradiol phosphate, 80 mg/mo. The baseline levels were similar in both groups, but 6 mo after initiation of therapy, serum Lp (a) levels were decreased 50% in the estrogentreated group (P < 0.001) in contrast to a 20% increase (P < 0.01) in the orchidectomized group. Concomitantly, LDL cholesterol decreased by 30% and HDL cholesterol increased by almost 60% in the estrogen-treated patients. There was no relationship between the change in LDL cholesterol and Lp (a) reduction. In conclusion, Lp (a) levels in males were found to drastically decrease upon estrogen treatment and to increase after orchidectomy, suggesting that sex hormones, and particularly estrogens, exert a regulatory role on the serum Lp (a) level in man. (J. Clin. Invest. 1992. 89:1166-1171

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.

Henriksson¹,

Angelin²,

Berglund³

1992

J. Clin. Invest.

150

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“…According to findings of Floren et al (24), Lp(a) was taken up mainly by the LDL receptor pathway, while according to the results of Martmann-Moe & Berg (25), Lp(a) was taken up independently of the LDL receptor pathway. Another indication for a different catabolic pathway of LDL and Lp (a) is the observation that in hypercholesterolaemic patients the application of cholestyramine only resulted in a reduction of the plasma LDL level without any change of the Lp(a) level (26).…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Lipoprotein (a) (Lp(a)) to Risk Factors of Coronary Heart Disease: Initial results of the prospective epidemiological study on Company employees in Westfalia

Schriewer¹,

Assmann²,

Sandkamp³

et al. 1984

Clinical Chemistry and Laboratory Medicine

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Schriewer, Assmann, Sandkamp and Schulte: Lp(a) and risk factors of coronary heart disease 591 J. Clin. Chem. Clin. Biochem. Vol. 22, 1984, pp. 591-596 The Relationship of Lipoprotein (a) (Lp(a) (Received March 12/June 5, 1984) Summary: Lp (a) concentrations were determined in 987 male and 477 female Company employees in Westfalia, in the age ränge 17-70 years. These values were then related to age and to the following risk factors: obesity, smoking, hypertension, hypertriglyceridaemia, hypercholesterolaemia, hyperbetalipoproteinaemia, hypoalphalipöproteinaemia, hyperglycaemia and hyperuricaemia.The Lp(a) values showed a similar markedly skewed distribution for both men and women. The median for men was 0.039 g/l, for women 0.050 g/l. In both sexes only about 25% of all Lp(a) values were above 0.10 g/l. Raised Lp(a) values (>0.30 g/l) were föund in 6.5% of males and in 6.1% of females.A significantly higher frequency of raised Lp(a) values (>0.30 g/l) was found in: post-menopausal women (11.3% äs against 4.1%, p < 0.01); females with hypercholesterolaemia (19.0% when cholesterol values were ^6.73 mmol/1, 10.8 % when cholesterol values were between 5.70-6.72 mmöl/1, 3.0% when cholesterol values were <5.70 mmol/1, p < 0.001); and females with hyperbetalipoproteinaemia (22.6% when LDL cholesterol values were 5*4.92 mmol/1, 5.0% when LDL cholesterol values were <4.92 mmol/1, p < 0.001).12.0% of men with hypoalphalipoproteinaemia (HDL cholesterol values <0.907 mmol/1) had Lp(a) values >0.30 g/l, äs against 5.5% of men with HDL cholesterol values ^0.907 mmol/1 (p < 0.01).This percentage rate increased to 16.9% when hypertriglyceridaernia (^2.28 mmol/1 triglycerides) was also present. All other risk factors which were examined and their combinations had no significant influence on the prevalence of raised Lp (a) .concentrations. Beziehung von Lipoprotein (a) (Lp (a)) zu Risikofaktoren der koronaren Herzkrankheit: Erste Ergebnisse der prospektiven epidemiologischen Studie bei Betriebsangehörigen in WestfalenZusammenfassung: Bei 987 männlichen und 477 weiblichen Betriebsangehörigen in Westfalen im Alter von 17-70 Jahren wurden die Lp(a)-Konzentrationen im Serum bestimmt und zum Alter und zu folgenden Risikofaktoren in Beziehung gesetzt: Übergewicht, Rauchen, Hypertonie, Hypertriglyceridämie, Hypercholesterinämie, Hyperbetalipoproteinämie, Hypoalphalipoproteinämie, Hyperglykämie und Hyperurikämie.

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“…Mean serum TG was decreased by 45.6% (P,~0.001). Two investigators (8,9) reported a decrease of TG by 44,6% and 43% respectively. The decrease observed In the present study is in agreement with that observed by the above workers.…”

Section: Resultsmentioning

confidence: 95%

A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India

Sharma

1997

Indian J Clin Biochem

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Effects of three drugs, Gemfibrozil, Diltiazem and Isosorbide dinitrate (ISDN) on various lipid parameters were studied in patients with ischemic heart disease (IHD) with positive treadmill stress response. Gemfibrozil and diltiazem significantly lowered the levels of serum total lipids (TL), triglycerides (TG), phospholipids (PL), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), and increased the levels of serum high density lipoprotein cholesterol (HDL-C) significantly. However, patients administered with ISDN showed a significant increase in all the lipid parameters except HDL-C, which showed a significant decrease.

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Diverging effects of cholestyramine on apolipoprotein B and lipoprotein Lp(a)

Cited by 149 publications

References 22 publications

Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.

Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.

The Relationship of Lipoprotein (a) (Lp(a)) to Risk Factors of Coronary Heart Disease: Initial results of the prospective epidemiological study on Company employees in Westfalia

A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India

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