Diverse Chromobox Family Members: Potential Prognostic Biomarkers and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma

Hu, Kuan; Yao, Lei; Zhou, Lei; Li, Juanni

doi:10.2147/ijgm.s350783

Cited by 4 publications

(5 citation statements)

References 53 publications

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“…These genetic and epigenetic changes lead to the downregulation of CBX7 in BCs. Moreover, loss of CBX7 expression has been reported in primary human tumors of the blood [14], brain [22], head and neck [16], lung [20], skin [17], stomach [21], and ovary [15]. Moreover, the knockout of the Cbx7 gene in mice resulted in the spontaneous development of lung and liver tumors [26].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have revealed the distinct Integrative Analysis of Genetic and Epigenetic Alterations in the CBX7 Gene Reveals Oncol Insights.2023;2:691 functions among CBX family members in cancer. For example, CBX3 was found to be upregulated, whereas CBX7 was downregulated in many types of human cancer [14][15][16][17][18][19][20][21][22]. Some studies have shown that CBX3 transcriptionally suppresses the p21 gene to promote cell proliferation [23][24][25], while CBX7 transcriptionally suppresses CCNE1 expression to inhibit cell proliferation [26].…”

Section: Introductionmentioning

confidence: 99%

“…These studies indicate that some CBX genes function as oncogenes and others act as tumor suppressor genes. Moreover, the expression of many CBX genes has a prognostic impact on human cancer [14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Integrative Analysis of Genetic and Epigenetic Alterations in the CBX7 Gene Reveals Its Tumor-Suppressive Function by Regulating the Cell Cycle in Human Breast Cancer

Cai¹,

Chang²,

Pérez-Losada³

et al. 2023

Oncol Insights

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CBX7 is a member of the chromobox gene family, which plays an important role in epigenetic transcriptional regulation. In this study, we found that compared to normal mammary tissues, mRNA levels of CBX7 are consistently significantly downregulated in breast cancers (BCs) across different datasets. Integrative multiomics analysis revealed the genetic and epigenetic mechanisms for the loss of CBX7 expression in BCs. Lower expression levels of CBX7 are significantly associated with shorter overall, disease-free, and distant metastasis-free survival of patients with BC. These prognostic impacts of CBX7 are independent of estrogen receptor status and PAM50 molecular subtypes. Coexpression analysis identified 207 genes consistently coexpressed with CBX7 (157 negatively and 50 positively). Gene Ontology, KEGG, and Reactome enrichment analysis revealed that cell cycle‑, DNA replication‑, and mitosis-related pathways are significantly overrepresented within the set of CBX7 negatively coexpressed genes, suggesting that CBX7 functions as a suppressor of the cell cycle. Moreover, transcription factor enrichment analysis detected the E2F family of transcription factors significantly associated with CBX7 negatively coexpressed genes, consistent with E2F function regulating the cell cycle. Furthermore, we found that loss of CBX7 expression significantly increases genomic instability and tumor mutation burden. Our findings indicate that CBX7 acts as a tumor suppressor in BC through its potential role in the negative regulation of cell proliferation and the maintenance of genome integrity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrative Analysis of Genetic and Epigenetic Alterations in the CBX7 Gene Reveals Its Tumor-Suppressive Function by Regulating the Cell Cycle in Human Breast Cancer

Cai¹,

Chang²,

Pérez-Losada³

et al. 2023

Oncol Insights

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“…We further evaluated the prognostic role of three candidate genes in OC with the help of Kaplan-Meier plotter ( http://kmplot.com/analysis/ ), an online public resource retrieving gene expressions and survival data from public cancer databases such as TCGA for prognostic analysis [ 22 ]. GEPIA2.0 ( http://gepia.cancer-pku.cn/ ) and UALCAN databases ( http://ualcan.path.uab.edu/index.html ) were employed to show the differential mRNA and protein expression of PRNP in OC.…”

Section: Methodsmentioning

confidence: 99%

Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer

Zhang

Zhou

et al. 2022

Journal of Immunology Research

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Background. Ovarian cancer (OC) seriously threatens women’s life. Ferroptosis plays an essential role in the initiation and development of OC. However, more molecular targets and mechanisms for ferroptosis in OC remain to be further elucidated. Methods. Several OC datasets were integrated in this study and three candidate genes including PRNP were further screened out as the ferroptosis-related gene which was differentially expressed in OC. Then, comprehensive evaluations concerning gene expression, clinical implication, in vitro validation of expression and functional experiments, prediction of downstream molecules and related signal pathways, and immune-modulating function were performed. Results. PRNP was the only downregulated ferroptosis-related gene with prognostic value for OC patients. The decreased mRNA and protein expression was verified in OC tissues and cell lines. PRNP was significantly correlated with cancer stages, primary therapy outcomes, and age in OC patients. Moreover, we found that overexpression of PRNP inhibited the proliferation, migration, and invasion ability of OC cells through in vitro experiments. PRNP was enriched to the Ras signaling pathway. PRNP expression was positively correlated with the infiltration of immune cells, such as mast cells, T effector memory cells, plasmacytoid DC cells, NK cells, and eosinophils. In addition, the association of PRNP with other immune signatures was also found. Conclusion. This study demonstrated for the first time showed that ferroptosis-related gene PRNP exerted a tumor suppressive role in OC and the aberrant expression and function of PRNP making it a potential novel biomarker for OC diagnosis, prognosis, and response to immunotherapies.

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“…Head and neck squamous cell carcinoma (HNSC) is the most common form of head and neck cancer [ 1 ]. HNSC is the sixth most prevalent cancer worldwide [ 2 ]; annually, the number of new cases exceeds 600,000 cases [ 3 ]. HNSCs are malignant tumors of a paranasal sinus, pharynx, larynx, and oral cavity epithelial cells [ 4 ].…”

Section: Forewordmentioning

confidence: 99%

The Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration

Huang

Zhao

et al. 2022

Journal of Oncology

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Background. Head and neck squamous cell carcinoma (HNSC) is one of the most common malignancies, and identification of HNSC biomarkers is critical. LIM Domain And Actin Binding 1 (LIMA1) is involved in actin cytoskeleton regulation and dynamics. The role of LIMA1 in HNSC is unclear. This is the first study to investigate the expression of LIMA1 in HNSC patients and its prognostic value, potential biological functions, and impact on the immune system. Methods. Gene expression and clinicopathological analysis, enrichment analysis, and immune infiltration analysis were all based on data from The Cancer Genome Atlas (TCGA) with additional bioinformatics analysis. Statistical analysis was performed using TIMER and ssGSEA to analyze the immune response to LIMA1 expression in HNSCs. In addition, Gene Expression Omnibus (GEO), Kaplan–Meier(K-M) survival analysis, and data from the Human Protein Atlas (HPA) were used to validate the results. Results. LIMA1 played a key role as an independent prognostic factor in HNSC patients. GSEA found that LIMA1 is associated with promoting cell adhesion and suppressing immune function. LIMA1 expression was significantly correlated with infiltration of B cells, CD8+ T cells, CD4+ T cells, dendritic cells, and neutrophils and was coexpressed with immune-related genes and immune checkpoints. Conclusion. The expression of LIMA1 is increased in HNSC, and the high expression of LIMA1 is associated with poor prognosis. LIMA1 may affect tumor development by regulating tumor-infiltrating cells in the tumor microenvironment (TME). LIMA1 may be a potential target for immunotherapy.

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Diverse Chromobox Family Members: Potential Prognostic Biomarkers and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma

Cited by 4 publications

References 53 publications

Integrative Analysis of Genetic and Epigenetic Alterations in the CBX7 Gene Reveals Its Tumor-Suppressive Function by Regulating the Cell Cycle in Human Breast Cancer

Integrative Analysis of Genetic and Epigenetic Alterations in the CBX7 Gene Reveals Its Tumor-Suppressive Function by Regulating the Cell Cycle in Human Breast Cancer

Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer

The Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration

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