Diverse cutaneous manifestation of Langerhans cell histiocytosis: a 10-year retrospective cohort study

Poompuen, Supattarawadee; Chaiyarit, Jitjira; Techasatian, Leelawadee

doi:10.1007/s00431-019-03356-1

Cited by 22 publications

(20 citation statements)

References 22 publications

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“…Poompuen, et al, han señalado cómo la similitud con la dermatitis seborreica puede retrasar el diagnóstico por la dificultad de distinguir las lesiones de una y otra condición y, además, porque la dermatitis seborreica es una entidad comúnmente observada en la edad pediátrica, como en el presente caso. Las lesiones óseas asociadas con la dermatitis seborreica pueden ser la clave para una detección temprana de la histiocitosis de células de Langerhans 8 , la cual puede sospecharse ante esta asociación y la poca mejoría con los tratamientos instaurados.…”

Section: Discussionunclassified

Histiocitosis de células de Langerhans: reporte de caso y revisión de la literatura

et al. 2021

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La histiocitosis de células de Langerhans comprende un grupo heterogéneo de enfermedades inflamatorias cuyos principales componentes celulares son las células dendríticas y los macrófagos. El infiltrado inflamatorio puede afectar la piel y otros órganos, y el resultado clínico varía de leve a letal, dependiendo del subconjunto de células involucradas y el compromiso multisistémico. La demora en el diagnóstico puede ocurrir debido a su presentación inespecífica y a que los médicos tratantes no suelen sospecharla.Se reporta el caso de una lactante mayor a la cual, a pesar de múltiples consultas con síntomas inespecíficos pero característicos de la enfermedad, solamente se le pudo hacer el diagnóstico gracias a los hallazgos histopatológicos.

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Section: Discussionunclassified

Histiocitosis de células de Langerhans: reporte de caso y revisión de la literatura

et al. 2021

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“…Although the cutaneous lesion was superficially similar to IDD, closere inspection revealed petechial hemorrhagic lesions (arrow signs). The finding of petechiae/ hemorrhagic cutaneous signs was a clue that allowed for the early detection of LCH in this patient [ 16 ]. Moreover, there were other cutaneous lesions (such as hemorrhagic seborrheic dermatitis-like lesions) on the patient’s scalp, petechiae hemorrhage on the trunk, and hepatosplenomegaly, which supported the diagnosis of LCH.…”

Section: Discussionmentioning

confidence: 99%

Diaper rashes can indicate systemic conditions other than diaper dermatitis

2020

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Background Although the majority of rashes in the diaper area are caused by irritation from urine and feces, irritant diaper dermatitis; IDD, there are some less common but potentially serious cutaneous eruptions associated with systemic diseases that should not be discounted. Methods This prospective descriptive study aimed to explore variation in cutaneous disease in the diaper area. It was conducted as a prospective descriptive study between October 2016 and November 2019 in the pediatric department of a tertiary-level hospital. Results Three hundred consecutive patients with rashes in the diaper area were enrolled. The most common diagnosed was IDD (125 cases; 41.7%), followed by rashes exacerbated by the diaper (101 cases; 33.67%) and non-diaper-related rashes (74 cases; 24.67%). Conclusions Our finding suggests that when diagnosing rashes that occur in the diaper area, general pediatricians should consider, in addition to IDD, the possibility of less-common conditions. The simultaneous presence of cutaneous lesions at other sites was linked to diagnoses of systemic diseases other than IDD, (P < 0.001).

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“…The incidence of LCH is low, with anywhere from 2 to 9 cases per million children per year reported [10]. The incidence of LCH peaks between 1 and 4 years of age worldwide, and there is a slight male predominance [11].…”

Section: Discussion/conclusionmentioning

confidence: 99%

A Newborn Female with a Diffuse Rash

Holcomb

Menge

et al. 2019

Dermatopathology

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Langerhans cell histiocytosis is a rare and clinically heterogeneous group of dendritic histiocytic disorders with typical onset in the neonatal period or infancy, although it can present at any age. Histiocytes accumulate in one or more organs, leading to a variable clinical presentation of disease. We report a case of biopsy-proven Langerhans cell histiocytosis in a newborn and discuss the workup and management of this disease, along with reviewing its clinical variants.

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Diverse cutaneous manifestation of Langerhans cell histiocytosis: a 10-year retrospective cohort study

Cited by 22 publications

References 22 publications

Histiocitosis de células de Langerhans: reporte de caso y revisión de la literatura

Histiocitosis de células de Langerhans: reporte de caso y revisión de la literatura

Diaper rashes can indicate systemic conditions other than diaper dermatitis

A Newborn Female with a Diffuse Rash

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