Diverse families of transposable elements affect the transcriptional regulation of stress-response genes in Drosophila melanogaster

Villanueva‐Cañas, José Luis; Horváth, Vivien; Aguilera, L.; González, Josefa

doi:10.1093/nar/gkz490

Cited by 47 publications

(71 citation statements)

References 81 publications

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“…A recent study performed using bioinformatic prediction coupled with Chip-seq data has revealed a significant enrichment of stress-related TFBSs in TEs [85], definitively supporting the idea that TEs are involved in stress responses.…”

Section: Tes As Promoter Suppliersmentioning

confidence: 66%

“What You Need, Baby, I Got It”: Transposable Elements as Suppliers of Cis-Operating Sequences in Drosophila

Moschetti

Palazzo

Lorusso

et al. 2020

Biology

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Transposable elements (TEs) are constitutive components of both eukaryotic and prokaryotic genomes. The role of TEs in the evolution of genes and genomes has been widely assessed over the past years in a variety of model and non-model organisms. Drosophila is undoubtedly among the most powerful model organisms used for the purpose of studying the role of transposons and their effects on the stability and evolution of genes and genomes. Besides their most intuitive role as insertional mutagens, TEs can modify the transcriptional pattern of host genes by juxtaposing new cis-regulatory sequences. A key element of TE biology is that they carry transcriptional control elements that fine-tune the transcription of their own genes, but that can also perturb the transcriptional activity of neighboring host genes. From this perspective, the transposition-mediated modulation of gene expression is an important issue for the short-term adaptation of physiological functions to the environmental changes, and for long-term evolutionary changes. Here, we review the current literature concerning the regulatory and structural elements operating in cis provided by TEs in Drosophila. Furthermore, we highlight that, besides their influence on both TEs and host genes expression, they can affect the chromatin structure and epigenetic status as well as both the chromosome's structure and stability. It emerges that Drosophila is a good model organism to study the effect of TE-linked regulatory sequences, and it could help future studies on TE-host interactions in any complex eukaryotic genome.

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Section: Tes As Promoter Suppliersmentioning

confidence: 66%

“What You Need, Baby, I Got It”: Transposable Elements as Suppliers of Cis-Operating Sequences in Drosophila

Moschetti

Palazzo

Lorusso

et al. 2020

Biology

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“…Note that while no mortality after 9 h of malathion exposure was found for SE-Sto and RAL-375, 15% and 25% mortality was found for RAL-177 and iso-1, respectively. [33,49]. We checked whether any of the 17 TEs located nearby upregulated hub genes contained binding sites for cnc, the major transcription factor in xenobiotic and oxidative stress response [60].…”

Section: Resultsmentioning

confidence: 99%

“…regulation of signalling 20 (1) 48 (4) 38 (9) 7 (2) 10 (4) 38 (9) 31 (7) 3 (1) 54 (11) 31 (8) 27 ( 135 (1) 119 (1) 316 (2) 389 (2) 223 (1) 824 (1) -12 -4 0 enrichment score [33,49]. Note that four hub genes nearby TEs are present both in RAL-177 and in iso-1.…”

Section: (E) Half Of the Transposable Elements Located In Open Chromamentioning

confidence: 99%

Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster

Salces-Ortiz

Vargas-Chávez

Guio

et al. 2020

Phil. Trans. R. Soc. B

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“…For TFBS (Table 1), we used conSite website to screen all TFBS from insect in our sequences (Sandelin et al , 2004). To complete our analysis, we used the TFBS obtained from Villanueva-Cañas et al (2019) and we extracted PFM (position frequency matrix) of the 14 TFBS from the JASPAR2018 database (v.1.1.1) (Parcy et al , 2017). Then, we used TFBSTools (v.1.22.0) package from R software (v. 3.6.0) to convert in PWM (position weight matrix), and then search on the 6 lines and the reference genome of D. suzukii (Paris et al, 2020; R Core Team, 2019; Tan and Lenhard, 2016).…”

Section: Methodsmentioning

confidence: 99%

Drosophila suzukiioxidative stress response involvesJhehgene cluster but not transposable elements

Marin

Jacquet

Henri

et al. 2020

Preprint

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statement 30 The responses to oxidative stress of the invasive species, Drosophila suzukii, show variability 31 between genotypes related to their invasion status. The genes of the juvenile hormone epoxide 32 hydrolase cluster are involved in this response. 33 34 ABSTRACT 35The study of the mechanisms involved in adaptation remains a timely issue, particularly in the 36 context of global changes. To better understand these mechanisms of rapid adaptation, invasive 37 species are a good model because they are subjected to new and/or different environmental 38 factors. Using different lines of different geographical origin of the invasive pest Drosophila 39 suzukii, we characterized the phenotypic response to oxidative stress. Subsequently, we tested 40 the involvement of the Jheh gene cluster in this response and the possible role of transposable 41 elements. We show that the resistance to oxidative stress of the lines appears to be related to 42 their invasive status and we confirm the role of the Jheh gene cluster in this response. We have 43 not identified any transposable elements in this gene region that could influence the expression 44 of the gene. 45 46 phenotypes in different environments (Ghalambor et al., 2015) has been proposed as one of the 52 most promising explanations for invasive success, particularly in the case of founder population 53 depleted of genetic variation (Estoup et al., 2016; Marin et al., 2019). Among deleterious 54 environments that can be encountered by invasive species, oxidative stress caused by 55 phytosanitary products is one of them. The invasive pest, Drosophila suzukii, is a good model to 56 investigate the adaptive process during invasion (Gibert et al., 2016). This species which belong 57 to the group of the fruit fly D. melanogaster, originally comes from Asia and was detected 58 simultaneously both in North America (U.S.A) and in Europe in 2008. North America was invaded 59 by native Japan populations derived from Hawaii. In Europe, several introductions were detected 60 from U.S.A and from China (Fraimout et al., 2017). Currently, D. suzukii is present in both North 61 and South America, in Europe from the south (Spain) to the East (Poland, Ukraine) and it has 62 also been observed in Russia (CABI, 2020; Lavrinienko et al., 2017). 63Characterization of the phenotypic and molecular responses of D. suzukii to changing 64 environmental conditions may provide information to the mechanisms involved in the ability of 65 invasive species to cope with environmental variation. Paraquat (N,N′-dimethyl-4,4′-bipyridinium 66 dichloride) is one of the most widely used herbicide in the world leading to the production of ROS 67 (reactive oxygen species) (Tsai, 2018). Oxidative stress due to the use of paraquat in the field 68 has also been used in the laboratory as a good proxy for studying stress resistance (Bus J S and 69 Gibson J E, 1984; Rzezniczak et al., 2011). Paraquat was banned since 2007 in Europe but is 70 still used in many other regions like in U.S.A or Japan. Paraquat exp...

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Diverse families of transposable elements affect the transcriptional regulation of stress-response genes in Drosophila melanogaster

Cited by 47 publications

References 81 publications

“What You Need, Baby, I Got It”: Transposable Elements as Suppliers of Cis-Operating Sequences in Drosophila

“What You Need, Baby, I Got It”: Transposable Elements as Suppliers of Cis-Operating Sequences in Drosophila

Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster

Drosophila suzukiioxidative stress response involvesJhehgene cluster but not transposable elements

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