2023
DOI: 10.1101/2023.12.08.570793
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Diverse Genetic Contexts of HicA Toxin Domains Propose a Role in Anti-Phage Defense

Kenn Gerdes

Abstract: Toxin – antitoxin (TA) modules are prevalent in prokaryotic genomes, often in substantial numbers. For instance, theMycobacterium tuberculosisgenome alone harbors close to 100 TA modules, half of which belong to a singular type. Traditionally ascribed multiple biological roles, recent insights challenge these notions and instead indicate a predominant function in phage defense. TAs are often located within Defense Islands, genomic regions that encode various defense systems. The analysis of genes within Defens… Show more

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