Diverse Glial Cell Line-Derived Neurotrophic Factor (GDNF) Support Between Mania and Schizophrenia: A Comparative Study in Four Major Psychiatric Disorders

Tunca, Zeliha; Akdede, B. Kıvırcık; Özerdem, Ayşegül; Alkın, Tunç; Polat, Selma; Ceylan, Deniz; Bayın, M.; Koçuk, Neşe; Şimşek, Şeref; Resmi, Halil; Akan, Pınar

doi:10.1016/j.eurpsy.2014.11.003

Cited by 52 publications

(30 citation statements)

References 80 publications

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“…Interestingly, serum GDNF levels have been correlated with mood assessments. For instance, levels of GDNF were lower in patients suffering from depression as compared with healthy controls (Diniz et al 2012;Lin & Tseng 2015), and increased serum GDNF levels were reported during the manic phase in bipolar patients (Tunca et al 2015). Unfortunately, administration of GDNF into the cerebral ventricles had no antidepressant effects in a genetic model of depression (Naumenko et al 2013).…”

Section: Gdnf and Psychiatric Disordersmentioning

confidence: 99%

GDNF and alcohol use disorder

et al. 2018

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Glial cell line-derived neurotrophic factor (GDNF) has been extensively studied for its role in the development and maintenance of the midbrain dopaminergic system, although evidence suggests that GDNF also plays a role in drug and alcohol addiction. This review focuses on the unique actions of GDNF in the mechanisms that prevent the transition from recreational alcohol use to abuse. Specifically, we describe studies in rodents suggesting that alcohol acutely increases GDNF expression in the ventral tegmental area, which enables the activation of the mitogen-activated protein kinase signaling pathway and the gating of alcohol intake. We further provide evidence to suggest that GDNF acts in the ventral tegmental area via both nongenomic and genomic mechanisms to suppress alcohol consumption. In addition, we describe findings indicating that when this endogenous protective pathway becomes dysregulated, alcohol intake levels escalate. Finally, we describe the potential use of GDNF inducers as a novel therapeutic approach to treat alcohol use disorder.

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Section: Gdnf and Psychiatric Disordersmentioning

confidence: 99%

GDNF and alcohol use disorder

et al. 2018

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“…It encodes a neurospecific factor involved in the differentiation of dopaminergic neurons and in synaptogenesis [Christophersen et al, 2007;Ledda et al, 2007]. GDNF levels are lower in SZ patients compared to healthy controls [Tunca et al, 2015]. With regard to gene networking, GDNF contributes to activation of the RET protein-tyrosine kinase [Jing et al, 1996], mediating neuronal survival [Coulpier et al, 2002].…”

Section: Functional Implication and Biological Interpretation Of Domementioning

confidence: 99%

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

et al. 2017

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Schizophrenia (SZ) is a pervasive neurodevelopmental disorder that entails social and cognitive deficits, including marked language problems. Its complex multifactorial etiopathogenesis, including genetic and environmental factors, is still widely uncertain. SZ incidence has always been high and quite stable in human populations, across time and regardless of cultural implications, for unclear reasons. It has been hypothesized that SZ pathophysiology may involve the biological components that changed during the recent human evolutionary history, and led to our distinctive mode of cognition, which includes language skills. In this paper we explore this hypothesis, focusing on the self-domestication of the human species. This has been claimed to account for many human-specific distinctive traits, including aspects of our behavior and cognition, and to favor the emergence of complex languages through cultural evolution. The “domestication syndrome” in mammals comprises the constellation of traits exhibited by domesticated strains, seemingly resulting from the hypofunction of the neural crest. It is our intention to show that people with SZ exhibit more marked domesticated traits at the morphological, physiological, and behavioral levels. We also show that genes involved in domestication and neural crest development and function comprise nearly 20% of SZ candidates, most of which exhibit altered expression profiles in the brain of SZ patients, specifically in areas involved in language processing. Based on these observations, we conclude that SZ may represent an abnormal ontogenetic itinerary for the human faculty of language, resulting, at least in part, from changes in genes important for the domestication syndrome and primarily involving the neural crest.

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“…Based on previous preclinical and clinical studies, there are several mechanisms, including neurotrophic signaling, cellular plasticity and activation of the hypothalamic-pituitary-adrenal may participate in the pathogenesis and progression of PSD 4 . As to the neurotrophic and neurochemical factors, structural and functional modification of the brain associated with synaptic plasticity has been suggested as an etiology of psychiatric disorders 5 . The degeneration or dysfunction of glial, especially astrocytes, plays a critical role in the pathogenesis of depression 6 .…”

Section: Introductionmentioning

confidence: 99%

The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder

Zhang

Jiang

Yue

et al. 2017

Sci Rep

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Previous studies have indicated that the level of glial cell line-derived neurotrophic factor (GDNF) may be correlated with stroke and depression. Here, we investigated whether GDNF can be a discriminant indicator for post stroke depression (PSD). 159 participants were divided into four groups: PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control (NC) group, and the protein and mRNA expression levels of GDNF in serum were measured. The results showed that only MDD group had statistical difference in protein and mRNA levels compared with the other three groups (Bonferroni test, P < 0.05). The results of receiver operating curve (ROC) analysis supported GDNF as general distinguishing models in PSD and MDD groups with the area under the curve (AUC) at 0.797 (P < 0.001) and 0.831 (P < 0.001) respectively. In addition, the Spearman analysis demonstrated that the GDNF protein level negatively correlated with the value of Hamilton depression rating scale (HAMD) in PSD patients (correlation coefficient = −0.328, P = 0.047). Together, these findings suggest the protein and mRNA expression levels of GDNF decreased in patients with depression. GDNF may serve as a potential biomarker for differential diagnosis of PSD from MDD patients.

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Diverse Glial Cell Line-Derived Neurotrophic Factor (GDNF) Support Between Mania and Schizophrenia: A Comparative Study in Four Major Psychiatric Disorders

Abstract: Our data confirmed the evidence of equally deficient neuronal support by BDNF in all major psychiatric illnesses, but suggested a diverse glial functioning between schizophrenia and mania.

Cited by 52 publications

References 80 publications

GDNF and alcohol use disorder

GDNF and alcohol use disorder

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder

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