Diverse Immune Responses to Orally Administered Heat-Killed Cell Preparation ofEnterococcus faecalisStrain EC-12 in Murine Immune Tissues

Yoshikawa, Tohru; Inoüe, Ryo; Yoshida, Yoko; Watanabe, Taiji; Bukawa, Wakoto; Ushida, Kazunari

doi:10.1271/bbb.90010

Cited by 16 publications

(16 citation statements)

References 21 publications

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“…These findings are in line with those found in the experiments with weaning piglets fed on a liquid fermented feed by lactobacilli (5). Orally administered LAB react with the mucosal immune system, which induces cytokine production (28). jejunum, and SI-7, as that of the ileum.…”

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confidence: 90%

Oral administration of Enterococcus faecalis EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice

et al. 2010

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Lactic acid bacteria, either alive or dead, can improve villous atrophy caused by weaning in both piglets and mice. In this experiment, we tried to detect the molecules involved in this phenomenon with a real-time RT-PCR array approach. Weaning pups of mice were administered either a suspension of an Enterococcus faecalis EC-12 dried cell preparation (EC-12) or saline for 11 consecutive days after weaning. The jejunal and ileal villous heights were measured histologically, and the expression levels of 86 genes were analyzed for the jejunal and ileal epithelial cells and the lamina propria (LP). EC-12 induced significantly higher villous height in the jejunum and the ileum. Interleukin (IL)-6, fibroblast growth factor (FGF)-7, -10, and -22, and the platelet-derived growth factor (PDGF) β in the jejunal and the ileal LP were the most enhanced genes by EC-12. The possible role of these molecules in the improvement of villous atrophy is discussed.

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confidence: 90%

Oral administration of Enterococcus faecalis EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice

et al. 2010

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“…EC-12 was selected because we have previously demonstrated 10-d oral administration of EC-12 successfully altered the cytokine/chemokine balance of both jejunal and ileal PPs toward a more inflammatory response. 4) In this study, detection of EC-12 inside PPs was also attempted for confirmation that EC-12 is taken up into PPs in a short time after the oral administration, in which case it is possible to alter the cytokine balance in PPs rapidly.…”

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confidence: 98%

“…Expression levels were determined by comparative Ct methods as described previously. 4) Mann-Whitney U test was done to analyze the results. Differences between groups were considered significant at p < 0:05.…”

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Rapid Induction of an Immune Response in Rat Peyer's Patch after Oral Administration of Enterococcus faecalis Strain EC-12

Inoüe

Tsukahara

Matsukawa

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…The day when the pups were delivered was regarded as day 0. All animals were housed under conventional circumstances in Kyoto Institute of Nutrition & Pathology, and the pups were not separated from their dams until day 15. Approximately half of the pups were forced to wean at day 16 (earlyweaned mice), while the other pups were allowed to keep suckling.…”

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A Mouse Model Study for the Villous Atrophy of the Early Weaning Piglets

et al. 2010

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ABSTRACT. Early weaning induces villous atrophy in the small intestine of piglets. We evaluated an influence of early weaning at 16 days old in mice for the use of villous atrophy model observed in early-weaned piglets. Five pregnant BALB/c mice were obtained and half of pups were weaned at 16 days old (early-weaned), while the others were allowed to suckle. Their small intestine was collected at 17, 18 and 19 days old in each group. Villous was shorting at 17 and 18 days old, but obscured at 19 days old. The gene expressions of epidermal and platelet-derived growth factor were associated with the villous height. Early weaning induced villous atrophy in the mouse small intestine as well as the piglets.KEY WORDS: early weaning, epidermal growth factor, mouse model, platelet-derived growth factor, villous atrophy.

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Diverse Immune Responses to Orally Administered Heat-Killed Cell Preparation ofEnterococcus faecalisStrain EC-12 in Murine Immune Tissues

Cited by 16 publications

References 21 publications

Oral administration of <I>Enterococcus faecal</I>is EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice

Oral administration of <I>Enterococcus faecal</I>is EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice

Rapid Induction of an Immune Response in Rat Peyer's Patch after Oral Administration of Enterococcus faecalis Strain EC-12

A Mouse Model Study for the Villous Atrophy of the Early Weaning Piglets

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