2023
DOI: 10.1101/2023.08.04.551922
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Diverse mechanisms control amino acid-dependent environmental alkalization byCandida albicans

Fitz Gerald S. Silao,
Valerie Diane Valeriano,
Erika Uddström
et al.

Abstract: Candida albicans has the remarkable capacity to neutralize acidic growth environments by releasing ammonia derived from the catabolism of amino acids. The molecular components and mechanisms controlling this capacity remain poorly understood. Here, we present an integrative model with the cytosolic NAD+-dependent glutamate dehydrogenase (Gdh2) as the principal component. We show that the alkalization defect of a strain lacking the SPS-sensor regulated transcription factor STP2 is due to the inability to fully … Show more

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