Diverse regulatory interactions of long noncoding RNAs

Kim, Tae Kyung; Shiekhattar, Ramin

doi:10.1016/j.gde.2016.03.014

Cited by 33 publications

(28 citation statements)

References 80 publications

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“…Studies of long non-coding (lnc)RNAs (lncRNAs) such as X inactive specific transcript (Xist), Kcnq1 opposite strand/antisense transcript 1 (Kcnq1ot1) and HOX transcript antisense RNA (HOTAIR), which associate with polycomb repressive complex 2 (PRC2) [2][3][4][5] , revealed that such specialized cellular RNAs could directly bind transcription and chromatin regulatory proteins and modulate their recruitment to genes. There is also evidence that other types of ncRNAs, such as those transcribed from enhancers, also contribute to gene regulation, in either their nascent or mature forms [6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Regulatory feedback from nascent RNA to chromatin and transcription

Skalska

Beltran-Nebot

Ule

et al. 2017

Nat Rev Mol Cell Biol

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Transcription and chromatin function are regulated by proteins that bind to DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. Unlike ncRNAs, nascent pre-mRNA was considered to be primarily a passive player in these processes. In this Opinion article, we describe recently identified interactions between nascent pre-mRNAs and regulatory proteins, highlight commonalities between the functions of nascent pre-mRNA and nascent ncRNA, and propose that both types of RNA have an active role in transcription and chromatin regulation.

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Section: Introductionmentioning

confidence: 99%

Regulatory feedback from nascent RNA to chromatin and transcription

Skalska

Beltran-Nebot

Ule

et al. 2017

Nat Rev Mol Cell Biol

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“…Moreover, lncRNAs can also interact with mediator subunits and regulate mediator complex formation [86,87]. One mode of lncRNA action is to trigger the formation of a stable RNA-DNA triplex to control TF binding specificity on promoter regions [88][89][90][91]. In Arabidopsis, COOLAIR, an antisense transcript originating from the 3 end of the floral repressor gene FLC, can reconfigure double-stranded DNA to a RNA-DNA hybrid and a single-stranded DNA (ssDNA) called 'R-loop' [92].…”

Section: Regulation Mechanism Of Lncrnas In Gene Transcriptionmentioning

confidence: 99%

The Emerging Role of Long Non-Coding RNAs in Plant Defense Against Fungal Stress

Zhang

Guo

et al. 2020

IJMS

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Growing interest and recent evidence have identified long non-coding RNA (lncRNA) as the potential regulatory elements for eukaryotes. LncRNAs can activate various transcriptional and post-transcriptional events that impact cellular functions though multiple regulatory functions. Recently, a large number of lncRNAs have also been identified in higher plants, and an understanding of their functional role in plant resistance to infection is just emerging. Here, we focus on their identification in crop plant, and discuss their potential regulatory functions and lncRNA-miRNA-mRNA network in plant pathogen stress responses, referring to possible examples in a model plant. The knowledge gained from a deeper understanding of this colossal special group of plant lncRNAs will help in the biotechnological improvement of crops.

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“…LncRNAs are long transcripts that are not translated into proteins and are emerging as important regulators of function in cells . They have also been linked to cancer progression and acquisition of drug resistance in tumor cells .…”

Section: Transfer Of Ev Rna Can Cause Transfer Of Drug Resistancementioning

confidence: 99%

Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles

2017

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Drug resistance remains a major barrier to the successful treatment of cancer. The mechanisms by which therapeutic resistance arises are multifactorial. Recent evidence has shown that extracellular vesicles (EVs) play a role in mediating drug resistance. EVs are small vesicles carrying a variety of macromolecular cargo released by cells into the extracellular space and can be taken up into recipient cells, resulting in transfer of cellular material. EVs can mediate drug resistance by several mechanisms. They can serve as a pathway for sequestration of cytotoxic drugs, reducing the effective concentration at target sites. They can act as decoys carrying membrane proteins and capturing monoclonal antibodies intended to target receptors at the cell surface. EVs from resistant tumor cells can deliver mRNA, miRNA, long noncoding RNA, and protein inducing resistance in sensitive cells. This provides a new model for how resistance that arises can then spread through a heterogeneous tumor. EVs also mediate cross-talk between cancer cells and stromal cells in the tumor microenvironment, leading to tumor progression and acquisition of therapeutic resistance. In this review, we will describe what is known about how EVs can induce drug resistance, and discuss the ways in which EVs could be used as therapeutic targets or diagnostic markers for managing cancer treatment. While further characterization of the vesiculome and the mechanisms of EV function are still required, EVs offer an exciting opportunity in the fight against cancer.

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Diverse regulatory interactions of long noncoding RNAs

Cited by 33 publications

References 80 publications

Regulatory feedback from nascent RNA to chromatin and transcription

Regulatory feedback from nascent RNA to chromatin and transcription

The Emerging Role of Long Non-Coding RNAs in Plant Defense Against Fungal Stress

Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles

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