Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus

Laukaitis, Christina M.; Dlouhy, Stephen R.; Emes, Richard D.; Ponting, Chris P.; Karn, Robert C.

doi:10.1186/1471-2148-5-40

Cited by 27 publications

(35 citation statements)

References 48 publications

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“…Furthermore, steroids released into mouse saliva and tears can be bound by androgen-binding proteins (ABPs) (96). ABPs are secretoglobins that form heterodimeric complexes with steroids bound at the dimer interface (96).…”

Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

“…ABPs are secretoglobins that form heterodimeric complexes with steroids bound at the dimer interface (96). The steroid-binding capacity of ABPs is reminiscent of the pheromone-binding properties of lipocalins (see below).…”

Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

“…The steroid-binding capacity of ABPs is reminiscent of the pheromone-binding properties of lipocalins (see below). The Abp gene family has undergone strikingly rapid evolution, with numerous species-specific gene expansions, as is observed for families of protein pheromones (96). Furthermore, ABPs are produced with striking sex specificity in various exocrine glands and are proposed to influence mate choice (96, 97).…”

Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

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Mammalian Pheromones

Liberles

2014

Annu. Rev. Physiol.

258

246

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Mammalian pheromones control a myriad of innate social behaviors and acutely regulate hormone levels. Responses to pheromones are highly robust, reproducible, and stereotyped and likely involve developmentally predetermined neural circuits. Here, I review several facets of pheromone transduction in mammals, including (a) chemosensory receptors and signaling components of the main olfactory epithelium and vomeronasal organ involved in pheromone detection; (b) pheromone-activated neural circuits subject to sex-specific and state-dependent modulation; and (c) the striking chemical diversity of mammalian pheromones, which range from small, volatile molecules and sulfated steroids to large families of proteins. Finally, I review (d ) molecular mechanisms underlying various behavioral and endocrine responses, including modulation of puberty and estrous; control of reproduction, aggression, suckling, and parental behaviors; individual recognition; and distinguishing of own species from predators, competitors, and prey. Deconstruction of pheromone transduction mechanisms provides a critical foundation for understanding how odor response pathways generate instinctive behaviors.

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Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

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Mammalian Pheromones

Liberles

2014

Annu. Rev. Physiol.

258

246

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“…These results suggest that the absence of typical intraspecific social behavior in male GTG-obese mice was associated with the total or partial failure to release a factor or factors from the submaxillary glands. Androgen binding proteins which are secreted by the mouse submaxillary gland and found in saliva, were shown to be involved in some behavioral responses such as mate selection [8, 39] and shown not to be secreted in urine [41]. Kimoto et al, [27] found that extract from submaxillary gland induced robust expression of c-fos in female VSNs.…”

Section: 0 Discussionmentioning

confidence: 99%

“…Laukaitis et al, [8] observed the expression of many androgen binding proteins (Abps) in various glands in the head and neck including the lacrimal and salivary glands. Salivary Abp mediates mate preference [8] and saliva is involved in sexual communication [9] indicating the presence of pheromones in the glands involved in saliva production. Currently, no data are available on the presence of volatile pheromones in saliva as has been shown for urine [10].…”

Section: 0 Introductionmentioning

confidence: 99%

Extracts from salivary glands stimulate aggression and inositol-1, 4, 5-triphosphate (IP3) production in the vomeronasal organ of mice

Taha

McMillon

Napier

et al. 2009

Physiology & Behavior

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Mammals use chemical cues to coordinate social and reproductive behaviors. Chemical cues are detected by the VNO organ (VNO), which is a cartilage-encased elongated organ associated with the vomer bone in the rostral nasal cavity. The resident intruder paradigm was utilized to examine the ability of saliva and its feeder exocrine glands, the submaxillary, parotid, and sublingual glands to mediate aggression in mice. Saliva and extracts from submaxillary and parotid glands, but not extracts from sublingual glands of male CD-1 mice, induced a greater number of attacks and lower latencies to sniff and attack (p < 0.05) and significantly increased IP3 production (p < 0.05) versus vehicle (PBS) in CD-1 male mice VNO. We further show that CD-1 male mouse saliva and submaxillary gland extract induced significantly more attacks and a lower latency to attack in lactating female CD-1 mice and produced significantly more inositol triphosphate (IP3), indicative of phospholipase Cβ signaling which mediates pheromonal activity, in CD-1 female VNO compared to PBS. Castrated CD-1 male mouse saliva, and exocrine gland extracts induced significantly less IP3 production in male VNO and less aggression by CD-1 males and lactating females compared to responses to normal CD-1 male mouse saliva and gland extracts. Thus, chemical cues present in saliva, submaxillary and parotid glands of CD-1 male mice are capable of stimulating aggression in male and female congenic mice which are correlated with significant production of IP3 in the VNO. Additionally, these stimulations of aggression and IP3 production are shown to be androgen-dependent.

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Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism

Ding

Xie

2015

Handbook of Olfaction and Gustation

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Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus

Cited by 27 publications

References 48 publications

Mammalian Pheromones

Mammalian Pheromones

Extracts from salivary glands stimulate aggression and inositol-1, 4, 5-triphosphate (IP3) production in the vomeronasal organ of mice

Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism

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