Diverse Synthetic Approaches and Biological Activities of Lucrative Pyrimidine- Triazine Hybrid Derivatives: A Review

Abstract

Pyrimidine and Triazine are rewarding pharmacophores as seen from their presence in different naturally and synthetically occurring drug molecules. Hybridization is a functional concept used in drug design. This updated review encompasses various synthetic routes, procedures that have been used to prepare molecular hybrids of Pyrimidine and Triazine, detailed structure-activity relationship, and molecular docking studies with patents granted. The most potent and promising hybrid compounds have also been identified. The study has revealed the synthetic feasibility of Pyrimidine- Triazine hybrids along with a plethora of potent biological activities such as Anticonvulsant, Antiviral, Anti-inflammatory, Analgesics, etc. This paper highlights the importance of coupling Pyrimidine and Triazine to provide better insight for medicinal chemists to further explore the hybrid for significant therapeutic effect.