Diverse Thalamocortical Short-Term Plasticity Elicited by Ongoing Stimulation

Díaz-Quesada, Marta; Martini, Francisco J.; Ferrati, Giovanni; Maravall, Miguel

doi:10.1523/jneurosci.2441-13.2014

Cited by 29 publications

(42 citation statements)

References 83 publications

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“…Hence a number of studies also demonstrated strong effects of calcium concentration on STP. In particular studies comparing STP in “classical” in vitro calcium concentration and in in vivo -like calcium concentration showed larger facilitation and/or reduced depression with the later [ 109 , 110 , 135 , 150 , 151 , 154 – 156 ].…”

Section: Discussionmentioning

confidence: 99%

Prominent facilitation at beta and gamma frequency range revealed with physiological calcium concentration in adult mouse piriform cortex in vitro

et al. 2017

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Neuronal activity is characterized by a diversity of oscillatory phenomena that are associated with multiple behavioral and cognitive processes, yet the functional consequences of these oscillations are not fully understood. Our aim was to determine whether and how these different oscillatory activities affect short-term synaptic plasticity (STP), using the olfactory system as a model. In response to odorant stimuli, the olfactory bulb displays a slow breathing rhythm as well as beta and gamma oscillations. Since the firing of olfactory bulb projecting neurons is phase-locked with beta and gamma oscillations, structures downstream from the olfactory bulb should be driven preferentially at these frequencies. We examined STP exhibited by olfactory bulb inputs in slices of adult mouse piriform cortex maintained in vitro in an in vivo-like ACSF (calcium concentration: 1.1 mM). We replaced the presynaptic neuronal firing rate by repeated electrical stimulation (frequency between 3.125 and 100 Hz) applied to the lateral olfactory tract. Our results revealed a considerable enhancement of postsynaptic response amplitude for stimulation frequencies in the beta and gamma range. A phenomenological model of STP fitted to the data suggests that the experimental results can be explained by the interplay between three mechanisms: a short-term facilitation mechanism (time constant ≈160 msec), and two short-term depression mechanisms (recovery time constants <20 msec and ≈140 msec). Increasing calcium concentration (2.2 mM) resulted in an increase in the time constant of facilitation and in a strengthening of the slowest depression mechanism. As a result, response enhancement was reduced and its peak shifted toward the low beta and alpha ranges while depression became predominant in the gamma band. Using environmental conditions corresponding to those that prevail in vivo, our study shows that STP in the lateral olfactory tract to layer Ia synapse allows amplification of olfactory bulb inputs at beta and gamma frequencies.

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Section: Discussionmentioning

confidence: 99%

Prominent facilitation at beta and gamma frequency range revealed with physiological calcium concentration in adult mouse piriform cortex in vitro

et al. 2017

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“…and synapses mediating thalamocortical input can have diverse temporal filtering properties [15]. However, how these capacities relate to sensory sequence learning in a living animal is unknown.…”

Section: Introductionmentioning

confidence: 99%

Learning a tactile sequence induces selectivity to action decisions and outcomes in the mouse somatosensory cortex

Bale

Bitzidou

Giusto

et al. 2020

Preprint

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Sequential temporal ordering and patterning are key features of natural signals used by the brain to decode stimuli and perceive them as sensory objects. To explore how cortical neuronal activity underpins sequence recognition, we developed a task in which mice distinguished between tactile 'words' constructed from distinct vibrations delivered to the whiskers, assembled in different orders. Animals licked to report the presence of the target sequence. Mice could respond to the earliest possible cues allowing discrimination, effectively solving the task as a 'detection of change'problem, but enhanced their performance when deliberating for longer. Optogenetic inactivation showed that both primary somatosensory 'barrel' cortex (S1bf) and secondary somatosensory cortex were necessary for sequence recognition. Twophoton imaging of calcium activity in S1bf layer 2/3 revealed that, in well-trained animals, neurons had heterogeneous selectivity to multiple task variables including not just sensory input but also the animal's action decision and the trial outcome (presence or absence of a predicted reward). A large proportion of neurons were activated preceding goal-directed licking, thus reflecting the animal's learnt response to the target sequence rather than the sequence itself; these neurons were found in S1bf as soon as mice learned to associate the rewarded sequence with licking. In contrast, learning evoked smaller changes in sensory responses: neurons responding to stimulus features were already found in naïve mice, and training did not generate neurons with enhanced temporal integration or categorical responses. Therefore, in S1bf sequence learning results in neurons whose activity reflects the learnt association between the target sequence and licking, rather than a refined representation of sensory features.

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“…Synapses exhibit functional heterogeneity in strength and short-term plasticity (STP; Atwood and Karunanithi, 2002; Dittman et al, 2000; Grande and Wang, 2011; Millar et al, 2002) which are critical for circuit computations (Abbott and Regehr, 2004; Chabrol et al, 2015; Chadderton et al, 2014; Diaz-Quesada et al, 2014). The function of synapses can be quantified using analysis methods based on the quantal theory of transmission (Katz, 1969), where synaptic strength elicited by a single presynaptic AP can be estimated by the product of three parameters: number of release sites (N), the probability that a single vesicle releases neurotransmitter (P v ), and the quantal size (q).…”

Section: Introductionmentioning

confidence: 99%

Distinct nanoscale calcium channel and synaptic vesicle topographies contribute to the diversity of synaptic function

Rebola

Reva

Kirizs

et al. 2018

Preprint

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SUMMARYThe nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown. We performed single bouton Ca2+ imaging, Ca2+ chelator competition, immunogold electron microscopic (EM) localization of VGCCs and the active zone (AZ) protein Munc13-1, at two cerebellar synapses. Unexpectedly, we found that weak synapses exhibited 3-fold more VGCCs than strong synapses, while the coupling distance was 5-fold longer. Reaction-diffusion modelling could explain both functional and structural data with two strikingly different nanotopographical motifs: strong synapses are composed of SVs that are tightly coupled (∼10 nm) to VGCC clusters, whereas at weak synapses VGCCs were excluded from the vicinity (∼50 nm) of docked vesicles. The distinct VGCC-SV topographical motifs also confer differential sensitivity to neuromodulation. Thus VGCC-SV arrangements are not canonical across CNS synapses and their diversity could underlie functional heterogeneity.

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Diverse Thalamocortical Short-Term Plasticity Elicited by Ongoing Stimulation

Cited by 29 publications

References 83 publications

Prominent facilitation at beta and gamma frequency range revealed with physiological calcium concentration in adult mouse piriform cortex in vitro

Prominent facilitation at beta and gamma frequency range revealed with physiological calcium concentration in adult mouse piriform cortex in vitro

Learning a tactile sequence induces selectivity to action decisions and outcomes in the mouse somatosensory cortex

Distinct nanoscale calcium channel and synaptic vesicle topographies contribute to the diversity of synaptic function

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