2015
DOI: 10.1038/ismej.2015.194
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Diversification of DnaA dependency for DNA replication in cyanobacterial evolution

Abstract: Regulating DNA replication is essential for all living cells. The DNA replication initiation factor DnaA is highly conserved in prokaryotes and is required for accurate initiation of chromosomal replication at oriC. DnaA-independent free-living bacteria have not been identified. The dnaA gene is absent in plastids and some symbiotic bacteria, although it is not known when or how DnaA-independent mechanisms were acquired. Here, we show that the degree of dependency of DNA replication on DnaA varies among cyanob… Show more

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Cited by 32 publications
(54 citation statements)
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“…The genome of UCYN-A lacks the dnaA gene as well. Recent studies suggested that DnaA is not essential for DNA replication and the lack of dnaA could suggest a preadaptation of the genome to enable the symbiosis (38). In UCYN-A and T. erythraeum , genes for DNA replication ( dnaE and RNaseHI), DNA topoisomerases, DNA gyrases and cell division ( ftsZ , mre , min ) had maximum transcript levels during the day (i.e., after midday), and minimum levels at night (Figure 3A and Figure S1).…”
Section: Resultsmentioning
confidence: 99%
“…The genome of UCYN-A lacks the dnaA gene as well. Recent studies suggested that DnaA is not essential for DNA replication and the lack of dnaA could suggest a preadaptation of the genome to enable the symbiosis (38). In UCYN-A and T. erythraeum , genes for DNA replication ( dnaE and RNaseHI), DNA topoisomerases, DNA gyrases and cell division ( ftsZ , mre , min ) had maximum transcript levels during the day (i.e., after midday), and minimum levels at night (Figure 3A and Figure S1).…”
Section: Resultsmentioning
confidence: 99%
“…Additionally, these distributions are useful for representing known coverage depth characteristics. For example, some researchers have described non-linear coverage depth trends over genome sequences in both bacteria and archaea (Chen et al, 2005;Watanabe et al, 2012;Hawkins et al, 2013;Pelve et al, 2013;Rudolph et al, 2013;Wendel, Courcelle & Courcelle, 2014;Wu et al, 2014;Maduike et al, 2014;Yang et al, 2015;Akiyama et al, 2016;Ohbayashi et al, 2016;Forsyth et al, 2018;Retkute et al, 2018). It was expected that this trend could be quantified by extension for the distributions proposed in the previous studies.…”
Section: Statistical Model To Estimate Replication Ratementioning
confidence: 94%
“…This approach narrows the range of measurement targets as some taxa such as archaea have two or more replication origins in a single replicon (Lundgren et al, 2004;Robinson et al, 2004;Andersson et al, 2010). It has also been suggested that some bacteria have multiple replication origins (Gao, 2015;Ohbayashi et al, 2016). In addition to growth estimation based on coverage depth, it is also difficult to predict replication origins from sequence features such as GC-skew in some microbes (Gao & Zhang, 2008;Sernova & Gelfand, 2008;Vieira-Silva & Rocha, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Previous work has shown that the DnaA protein is not needed for DNA replication in Synechocystis and that a dnaA null mutant grows as well as WT in BG-11 medium (Richter et al, 1998;Katayama et al, 2010;Ohbayashi et al, 2015). However, the effects on growth and ploidy under phosphate limiting conditions have not been examined.…”
Section: Dnaa Plays a Role In Controlling Ploidymentioning
confidence: 99%
“…The molecular details underpinning the regulation of DNA replication and ploidy in cyanobacteria remain unclear although ploidy has been positively correlated with cell size and internal protein concentration (Zheng and O'Shea, 2017) and is influenced by phosphate availability (Zerulla et al, 2016). Unusually, DNA replication in Synechocystis is asynchronous and does not occur at a defined origin (Ohbayashi et al, 2015), and the DnaA protein, which is an essential DNA replication initiation factor in most bacteria (Messer, 2002;Katayama et al, 2010), is not crucial for replication (Richter et al, 1998;Ohbayashi et al, 2015).…”
Section: Introductionmentioning
confidence: 99%