Diversified bioactivities of four types of naturally occurring quinochalcones

Zhao, Siyu; Lu, Xinmiao; Xiao, Cheng; Ning, Zhangchi; Zeng, Honglian; Ding, Xinzhe; Zhang, Yinhuan; Lü, Cheng; Liu, Yuanyan

doi:10.1016/j.fitote.2014.08.017

Cited by 6 publications

(5 citation statements)

References 94 publications

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“…In addition, the eight MiCGTb mutants not only recognized 3′-glucosyl phloretin ( 2b ) but also catalyzed 3′-dimethylallyl phloretin ( 15 ) to form a C -glucoside ( 15a ). Interestingly, these two bis- C -alkylation products can undergo spontaneous oxidation to afford quinol C -glucosides ( 2c and 15b ) at pH 8.0 (Figure S21), respectively, thus expanding the structural diversity. − …”

Section: Resultsmentioning

confidence: 99%

“…Tolerance of MiCGTb Mutants for NDP-Sugars. The sugar donors included UDP-α-D-glucose ( 16), TDP-α-Dglucose (17), UDP-α-D-galactose (18), UDP-β-L-rhamnose (19), UDP-β-L-arabinose (20), UDP-α-D-N-acetylglucosamine (21), UDP-α-D-xylose (22), UDP-α-D-glucuronic acid (23), UDP-β-L-fucose (24), UDP-α-D-N-acetylgalactosamine (25), GDP-α-D-mannose (26), and UDP-α-D-N-acetylgulosamine (27). The sugar donors 19, 20, and 27 were each prepared according to the literature.…”

Section: Acs Catalysismentioning

confidence: 99%

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Probing and Engineering Key Residues for Bis-C-glycosylation and Promiscuity of a C-Glycosyltransferase

et al. 2018

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C-Glycosyltransferases (CGTs) are powerful tools for the C-glycosylation of natural and unnatural products. However, CGTs able to catalyze bis-C-glycosylation are very rare and the key amino acids of which have not been uncovered. Here, we discovered a C-glycosyltransferase MiCGTb from Mangifera indica that has the capacity for bis-C-glycosylation. Further studies on active-site motifs revealed that I152 of MiCGTb was the critical amino acid residue for the second C-glycosylation and its S60/V100/T104 residues were pivotal for bis-C-glycosylation activity. Moreover, we developed a panel of variants with acceptor and donor promiscuity by site-directed mutagenesis. Among these variants, a mutant MiCGT-E152L displayed a broader acceptor scope for bis-C-glycosylation, and three mutants of MiCGTb exhibited sugar donor promiscuity toward structurally varied α-Dand β-Lglycosyl donors. Our work provides insights into the pivotal amino acid residues of CGTs for bis-C-glycosylation and biocatalytic tools to efficiently produce structurally diverse bis-C-glycosides with two identical or different sugar moieties in drug discovery.

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Section: Resultsmentioning

confidence: 99%

Section: Acs Catalysismentioning

confidence: 99%

Probing and Engineering Key Residues for Bis-C-glycosylation and Promiscuity of a C-Glycosyltransferase

et al. 2018

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“…Natural chalcones are an important class of natural compounds widely used in traditional and evidence‐based medicine (Matos et al, 2015). They have a diverse therapeutic challenge against several types of diseases, including, but not limited to, ischemic conditions, organ toxicities, and cancerous problems (Karimi‐Sales et al, 2018; León‐González et al, 2015; Zhao et al, 2014). At the same time, chalcones exhibit a high degree of safety when consumed at therapeutic doses.…”

Section: Effect Of Natural Chalcones On Different Types Of I/r Injurymentioning

confidence: 99%

The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review

Sayed

Gohar

Abd-alhameed

et al. 2022

Journal of Food Biochemistry

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Over the last few decades, extensive research has been conducted, yielding a detailed account of thousands of newly discovered compounds of natural origin and their biological activities, all of which have the potential to be used for a wide range of therapeutic purposes. There are multiple research papers denoting the central objective of chalcones, which have been shown to have therapeutic potential against various forms of ischemia. The various aspects of chalcones are discussed in this review regarding molecular mechanisms involved in the promising anti‐ischemic potential of these chalcones. The main mechanisms involved in these protective effects are Nrf2/Akt activation and NF‐κB/TLR4 suppression. Furthermore, in‐silico studies were carried out to discover the probable binding of these chalcones to Keap‐1 (an inhibitor of Nrf2), Akt, NF‐κB, and TLR4 protein molecules. Besides, network pharmacology analysis was conducted to predict the interacting partners of these signals. The obtained results indicated that Nrf2, Akt, NF‐κB, and TLR4 are involved in the beneficial anti‐ischemic actions of chalcones. Conclusively, the present findings show that chalcones as anti‐ischemic agents have a valid rationale. The discussed studies will provide a comprehensive viewpoint on chalcones and can help to optimize their effects in different ischemia. Practical applications Ischemic organ damage is an unavoidable pathological condition with a high worldwide incidence. According to the current research progress, natural chalcones have been proved to treat and/or prevent various types of ischemic organ damage by alleviating oxidative stress, inflammation, and apoptosis by different molecular mechanisms. This article displays the comprehensive research progress and the molecular basis of ischemic organ damage pathophysiology and introduces natural chalcones' mechanism in the ischemic organ condition.

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“…When G3 refer to very high significant P<0.001 compared to control (+Ve). As erythrocyte indices like mean cell volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC), in experiment, correlated with RBC, hemoglobin and hematocrit values (Karimungi and Joshi, 1996), then Carthamus tinctorius extract administration might provide the additional benefit of increasing blood fluidity by lowering blood viscosity, which can be of great value in the prevention of hemorheo-logical disorder-associated diseases in at risk patients (Zhao et al, 2014). Carthamus tinctorius extract predicted by spectrum-effect relationship analysis had good blood-activating effect.…”

Section: ‫مجلة‬ ‫النوعية‬ ‫التربية‬ ‫مجاالت‬ ‫في‬ ‫البحوث‬mentioning

confidence: 99%

دراسة التأثیرات المضادة للسمیة المحتملة لمستخلص نبات Carthamus tinctorius على الجرذان التی تسببها المرکبات الحلقیة غیر المتجانسة المحتویة على النیتروجین

زهران¹

2022

مجلة البحوث فی مجالات التربیة النوعیة

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Diversified bioactivities of four types of naturally occurring quinochalcones

Cited by 6 publications

References 94 publications

Probing and Engineering Key Residues for Bis-C-glycosylation and Promiscuity of a C-Glycosyltransferase

Probing and Engineering Key Residues for Bis-C-glycosylation and Promiscuity of a C-Glycosyltransferase

The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review

دراسة التأثیرات المضادة للسمیة المحتملة لمستخلص نبات Carthamus tinctorius على الجرذان التی تسببها المرکبات الحلقیة غیر المتجانسة المحتویة على النیتروجین

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