Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202

Abstract

Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC50 value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC50 value of 2.32 μM.

Research on Secondary Metabolites From the Soft Coral-Associated Fungus Aspergillus sydowii SCSIO41203 and Their Bioactivities

“…Screening of pancreatic lipase and AChE activities was conducted according to the literature. [13][14][15] In order to screen compounds with inhibitory activity, a mixture of compounds and AChE react at 30 °C; if the compounds inhibited AChE, which can decrease the amount of substrate degradation, corresponding with the reaction of 5-5 ′′ -Dithio-bis(2-nitrobenzoic acid) generating less yellow compound, namely at 405 nm lower absorption value. The cytotoxic against A549 of these compounds was tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide method.…”

Arthproliferins A–D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221

“…The molecular docking was conducted using the Schrödinger 2017-1 suite as described previously [32]. The crystal structures of human HIF-1α with Clioquinol inhibitor (PDB ID: 3KCX) and UQCRB (PDB ID: 3BCC) were collected from the protein data bank (http://www.pdb.org, accessed on 15 September 2023).…”

Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish

“…In recent years, a significant amount of secondary metabolites, such as peptides, terpenes, peptaibols, alkaloids, and flavonoids, have been isolated from Emericellopsis sp. [12][13][14]. To date, research on the bioactivities of secondary metabolites from Emericellopsis sp.…”