Diversion colitis in inflammatory bowel disease (IBD) is distinct from that in non-IBD: Reappraisal of diversion colitis

Fu, Zhiyan; Kmeid, Michel; Arker, Soe Htet; Lukose, Georgi; Lee, Edward C.; Lauwers, Gregory Y.; Lee, Hwajeong

doi:10.1016/j.humpath.2022.02.011

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Inflammatory bowel disease (IBD) is a noninfectious, chronic, and recurrent inflammation of the gastrointestinal tract. 1,2 Common symptoms of IBD include diarrhea, rectal bleeding, abdominal pain, fatigue, and weight loss. 3,4 It is important to diagnose IBD.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to colonoscopy, other procedures, such as upper endoscopy and sigmoidoscopy, can help the diagnosis of IBD, including common blood test that identifies inflammation. 2 Treatment of IBD mainly relies on anti-inflammatory drugs, immunosuppressants, and antibiotics, but many problems prevail with drug resistance. 5 Effective therapeutic drugs are to be developed to ameliorate symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative stress in inflammatory bowel disease by inhibiting NLRP3 and NF-κB signaling pathways

Zhang

Lai²,

Li³

et al. 2022

Allergol Immunopathol

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Objective: To investigate the effects of morroniside on inflammatory and oxidative stress in lipopolysaccharide (LPS)-induced inflammatory bowel disease (IBD) cell model. Methods: NCM460 cells were treated with 2-, 5-, or 10-μg/mL LPS for 24 h to develop an IBD cell model. MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) colorimet-ric assay was performed to uncover the role of morroniside on the viability of LPS-treated NCM460 cells. Flow cytometry and immunoblot assays were performed to confirm the effects of morroniside on the apoptosis of LPS-treated NCM460 cells. Quantitative polymerase chain reaction and enzyme-linked-immunosorbent serologic assays were performed to confirm the effects of morroniside on inflammatory and oxidative stress by measuring the levels of tumor necrosis factor-α, interleukin-1β, IL-6, superoxide dismutase, malondialdehyde, total antioxi-dant capacity, and myeloperoxidase. In addition, immunoblot and immunofluorescence assays were performed to detect the effects of morroniside on NLRP3 and NF-κB pathways. Results: Monosine attenuated LPS-induced injury of NCM460 cells. Monosine reduced LPS-induced inflammation in NCM460 cells. In addition, morroniside reduced LPS-induced oxidative stress in NCM460 cells. Mechanically, morroniside suppressed NLRP3 and NF-κB pathways, and alleviated LPS-induced inflammatory and oxidative stress in IBD. Conclusion: Morroniside could serve as a promising drug for treating IBD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative stress in inflammatory bowel disease by inhibiting NLRP3 and NF-κB signaling pathways

Zhang

Lai²,

Li³

et al. 2022

Allergol Immunopathol

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Role of ileal diversion in pediatric inflammatory bowel disease

Simard,

Kotamraju,

DeFazio

et al. 2024

J. pediatr. gastroenterol. nutr.

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Surgical intervention is often indicated in pediatric inflammatory bowel disease (IBD) for medically refractory disease or complications of severe disease. Specifically, surgical intervention via ileal diversion allows for fecal flow to be redirected away from diseased distal bowel and through an ileostomy. It is utilized in patients who have medically refractory colitis, severe perianal disease, or irreversible bowel damage. In patients with ulcerative colitis, it is primarily performed during a restorative proctocolectomy with ileal pouch anal anastomosis to protect the high‐risk anastomoses. In the setting of Crohn's disease, ileal diversion reduces the exposure of diseased distal intestine to pro‐inflammatory stool. During perioperative planning, it is crucial for the gastroenterologist to partner early with a multidisciplinary team including surgeons, nutritionists, wound ostomy care nurses, psychologists, and social workers. Patients should be assessed for malnutrition and should be optimized nutritionally with enteral or parenteral nutrition. As they are associated with increased risk of postoperative complications, corticosteroids should be significantly reduced or completely discontinued preoperatively. Though ileal diversion may reduce the complications associated with anastomosis, serious postoperative complications can include diversion colitis and high‐output fistulae. This review aims to provide an overview of the role of ileal diversion in the treatment of pediatric IBD to pediatric gastroenterologists to inform their medical decision‐making and discussions with patients and families.

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Diversion colitis in inflammatory bowel disease (IBD) is distinct from that in non-IBD: Reappraisal of diversion colitis

Cited by 2 publications

References 23 publications

Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative stress in inflammatory bowel disease by inhibiting NLRP3 and NF-κB signaling pathways

Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative stress in inflammatory bowel disease by inhibiting NLRP3 and NF-κB signaling pathways

Role of ileal diversion in pediatric inflammatory bowel disease

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