Diversities of &lt;i&gt;Anopheles gambiae ss&lt;/i&gt; and &lt;i&gt;Plasmodium falciparum&lt;/i&gt; in Minna, Nigeria

Omalu, I. C. J.; Eke, S. S.; Olayemi, Israel Kayode; Egwim, Evans Chidi; Yamman, H.U.; Ocha, I.M.; Ogunniyi, M.T.; Ajibaye, O.S.; Otuu, C.A.; Nnaji, C.I.; Inyama, P.U.

doi:10.4314/njpar.v40i2.2

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“…There was a significant difference (χ 2 =25.9, df=2, P< 0.001) between the frequency of FC27 and 3D7 alleles in the study area. [6] and Minna, Nigeria by Omalu et al [10] reported that FC27 had higher frequency than 3D7 alleles. In Sabah, East Malaysia and Bioko Island in Equatorial Guinea, it was shown that FC27 had higher frequency than 3D7 alleles in those areas [11,27].…”

Section: Resultsmentioning

confidence: 95%

“…Usually, the high intensity of malaria transmission in an areas is characterized by high parasite diversity, and infected individuals usually carry multiple parasite genotypes [10]. Thus in low malaria transmission areas parasite populations may have few genetic diversity leading to most infections being monoclonal [6].…”

Section: Resultsmentioning

confidence: 99%

“…The Genetic diversity is one of the predominant features of P. falciparum infections [9]. It survives the host's immune responses due to its diversity, which results from several factors such as recombination, chromosome rearrangements, antigenic variation and allelic polymorphism [10]. Genetic diversity in the parasite regulates transmission dynamics, disease severity, antimalarials drug resistance and impede the development of an effective vaccine against the malaria parasite, since antigenic diversity reduced the efficacy of acquired protective immunity to malaria [7,9,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Diversity and Molecular Surveillance of Antimalarial Drug Resistance of Plasmodium falciparum among Hospitals Patients in Benue State Nigeria

Adulugba

Amali

Manyi

et al. 2022

MRJI

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Introduction: Malaria is a febrile illness caused by parasites of the genus Plasmodium and transmitted by female Anopheles mosquitoes. The genetic diversity and antimalarial drug resistance of Plasmodium falciparum are some of the major challenges of malaria control programme in Nigeria. Aim: This study was aimed at determining the genetic diversity, and molecular surveillance of antimalarial drug resistance among patients attending Government hospitals in Benue State, Nigeria. Methodology: Plasmodium falciparum deoxyribonucleic acid was extracted from dried blood spots of 60 positive malariacases among the patients. The diversity of Plasmodium falciparum was done by genotyping 3D7 and FC27 families of merozoite surface protein- 2 alleles. The Plasmodium falciparum multidrug resistance 1 and Plasmodium falciparum kelch13 genes of Plasmodium falciparum were also amplified and assessed by restriction fragment length polymorphism (RFLP) to survey molecular resistance to antimalarial drugs. Results: The results showed that the frequency of 3D7 allele 37(61.7%) was higher than FC27 allele 18(30.0%). The frequency of merozoite surface protein- 2 infections with both allelic types was 5(8.3%). There was a significant difference in the distribution of the merozoite surface protein two alleles (χ2=25.9,df=2 P<.0.001). Both the Plasmodium falciparum multidrug resistance 1 Asparagine 86Tyrosine (N86Y) and Aspartic acid 1246Tyrosine (D1246Y), had 100 % mutant while the 100% while the Plasmodium falciparum kelch13 G449A had 100% wild type allele. Conclusion: The current study underscores the need for frequent monitoring of indicators of antimalaria drug resistance in Nigeria.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%