Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China

Hu, Geng; Jiang, Fachun; Luo, Qi; Zong, Kexin; Dong, Liyan; Mei, Guo-yong; Du, Haijun; Dong, Hongming; Song, Qinqin; Song, Juan; Xia, Zhiqiang; Gao, Chen; Han, Jun

doi:10.1128/spectrum.05340-22

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…There are additional noteworthy phenomena that deserve attention in this study. Consistent with previous studies, we observed that newly tick-borne viruses in China were closely related to strains found in Japan [ 47 ]. We also identified some viruses, such as YGTV, that were closely related to Russian strains.…”

Section: Discussionsupporting

confidence: 91%

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017

Wang,

Liu,

Sun

et al. 2023

Viruses

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In recent years, numerous viruses have been identified from ticks, and some have been linked to clinical cases of emerging tick-borne diseases. Chinese northeast frontier is tick infested. However, there is a notable lack of systematic monitoring efforts to assess the viral composition in the area, leaving the ecological landscape of viruses carried by ticks not clear enough. Between April and June 2017, 7101 ticks were collected to perform virus surveillance on the China–North Korea border, specifically in Tonghua, Baishan, and Yanbian. A total of 2127 Ixodes persulcatus were identified. Further investigation revealed the diversity of tick-borne viruses by transcriptome sequencing of Ixodes persulcatus. All ticks tested negative for tick-borne encephalitis virus. Transcriptome sequencing expanded 121 genomic sequence data of 12 different virus species from Ixodes persulcatus. Notably, a new segmented flavivirus, named Baishan Forest Tick Virus, were identified, closely related to Alongshan virus and Harz mountain virus. Therefore, this new virus may pose a potential threat to humans. Furthermore, the study revealed the existence of seven emerging tick-borne viruses dating back to 2017. These previously identified viruses included Mudanjiang phlebovirus, Onega tick phlebovirus, Sara tick phlebovirus, Yichun mivirus, and three unnamed viruses (one belonging to the Peribunyaviridae family and the other two belonging to the Phenuiviridae family). The existence of these emerging tick-borne viruses in tick samples collected in 2017 suggests that their history may extend further than previously recognized. This study provides invaluable insights into the virome of Ixodes persulcatus in the China–North Korea border region, enhancing our ongoing efforts to manage the risks associated with tick-borne viruses.

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Section: Discussionsupporting

confidence: 91%

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017

Wang,

Liu,

Sun

et al. 2023

Viruses

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Viral diversity in the European spruce bark beetle Ips typographus as revealed through high-throughput sequencing

Sutela,

Siitonen,

Ylioja

et al. 2024

Crop Protection

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Metatranscriptomic analysis reveals the diversity of RNA viruses in ticks in Inner Mongolia, China

Su,

Cui,

Xing

et al. 2024

PLoS Negl Trop Dis

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Background Ticks are widely distributed throughout China and are the second most prevalent pathogen vectors in the world, following only mosquitoes. Tick bites can lead to Lyme disease, forest encephalitis, and other illnesses that may result in death under severe circumstances. Materials and methods: Ticks collected from March 2021 to May 2023 were pooled and used in metatranscriptomic analyses to gain insight into the diversity and distribution of tick-borne viruses in Inner Mongolia. Next-generation sequencing (NGS) outcomes were validated, and viral prevalence across distinct tick species was determined through the application of polymerase chain reaction (PCR) paired with Sanger sequencing. Results A total of 20 RNA viruses belonging to at least 8 families, including Chuviridae, Flaviviridae, Solemoviridae, Nairoviridae, Partitiviridae, Phenuiviridae, Rhabdoviridae, and Totiviridae, and to unclassified families were identified by NGS. Five of the identified RNA viruses (Nuomin virus, Yezo virus, tick-borne encephalitis virus, Alongshan virus, and Beiji nairovirus) are considered human pathogens. A potential human pathogen, Mukawa virus, was also among the identified viruses. Ixodes persulcatus carried a significantly greater number of viral species than did Dermacentor nuttalli, Hyalomma marginatum, and Haemaphysalis concinna. The prevalence of coinfection with multiple viruses differed in I. persulcatus from Hinggan League and Hulun Buir, and Beiji nairovirus was the codominant virus species. Conclusions There is a remarkable diversity of RNA viruses harboured by ticks in Inner Mongolia, with variations observed in the distribution of these tick-borne viruses across different regions and tick hosts.

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Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China

Cited by 4 publications

References 52 publications

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017

Viral diversity in the European spruce bark beetle Ips typographus as revealed through high-throughput sequencing

Metatranscriptomic analysis reveals the diversity of RNA viruses in ticks in Inner Mongolia, China

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