The risk of diabetes will increase when there was any diabetes family history. The study aimed to determine the relationship of having diabetes family history with diet and physical activity among late adolescents. This study also determines the factors that influence diet and physical activity. This study was a mixed-method, which was done in two phases, quantitative followed by a qualitative study. Fifty late-adolescent (18-24 years old) involved in the quantitative study, and fourteen late-adolescent involved in the qualitative study. The subject for the quantitative study was a family member of the Chronic Disease Program in (Prolanis) in Puskesmas study area. The selection of fourteen subjects for qualitative study was proportionally based on variations arise from the quantitative study. The study showed that there was no significant association between life with diabetes family members in one home or not with diet and physical activity (p = 0,310 dan p = 0,297). Nor was there any association between having diabetes family history from first or second relative's degree with diet and physical activity (p = 0,276 dan p = 0,547). There was 92 percent of respondents had low fiber, high fat, and high sugar diet. This study found that factors influenced diet and physical activity were perceive susceptibility, perceived benefit, perceived barrier, and self-efficacy. There was no association between having diabetes family history with diet and physical activity. Support from family, friends, work environment or campus is needed to establish a healthy diet and physical activity, to prevent diabetes.