Diversity and circulation of Jingmen tick virus in ticks and mammals

Guo, Jingjing; Lin, Xian-Dan; Chen, Yanmei; Hao, Zong-yu; Wang, Zhao-xiao; Yu, Zhu-Mei; Lu, Miao; Li, Kun; Qin, Xin-Cheng; Wang, Wen; Holmes, Edward C.; Hou, Wei; Zhang, Yongzhen

doi:10.1093/ve/veaa051

Cited by 41 publications

(46 citation statements)

References 47 publications

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“…Taken together, our results show that the ALSV strains can be divided into Asian and European subgroups and, also, that there is a clear correlation with I. ricinus and I. persulcatus ticks, respectively. Our findings differs from the data about JMTV, where geographic isolation, rather than host species, may be the main driver of JMTV diversity [ 52 ].…”

Section: Discussioncontrasting

confidence: 99%

Geographical and Tick-Dependent Distribution of Flavi-Like Alongshan and Yanggou Tick Viruses in Russia

Kholodilov

Belova

Morozkin

et al. 2021

Viruses

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The genus Flavivirus includes related, unclassified segmented flavi-like viruses, two segments of which have homology with flavivirus RNA-dependent RNA polymerase NS5 and RNA helicase-protease NS3. This group includes such viruses as Jingmen tick virus, Alongshan virus, Yanggou tick virus and others. We detected the Yanggou tick virus in Dermacentor nuttalli and Dermacentor marginatus ticks in two neighbouring regions of Russia. The virus prevalence ranged from 0.5% to 8.0%. We detected RNA of the Alongshan virus in 44 individuals or pools of various tick species in eight regions of Russia. The virus prevalence ranged from 0.6% to 7.8%. We demonstrated the successful replication of the Yanggou tick virus and Alongshan virus in IRE/CTVM19 and HAE/CTVM8 tick cell lines without a cytopathic effect. According to the phylogenetic analysis, we divided the Alongshan virus into two groups: an Ixodes persulcatus group and an Ixodes ricinus group. In addition, the I. persulcatus group can be divided into European and Asian subgroups. We found amino acid signatures specific to the I. ricinus and I. persulcatus groups and also distinguished between the European and Asian subgroups of the I. persulcatus group.

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Section: Discussioncontrasting

confidence: 99%

Geographical and Tick-Dependent Distribution of Flavi-Like Alongshan and Yanggou Tick Viruses in Russia

Kholodilov

Belova

Morozkin

et al. 2021

Viruses

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“…2018 ; Dinçer et al. 2019 ; Guo et al. 2020 ) and was found to be related to human infection in Kosovo and China, respectively ( Emmerich et al.…”

Section: Discussionmentioning

confidence: 99%

Tick virome diversity in Hubei Province, China, and the influence of host ecology

Guo

et al. 2021

Virus Evolution

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Ticks are important vector hosts of pathogens which cause human and animal diseases worldwide. Diverse viruses have been discovered in ticks; however, little is known about the ecological factors that affect the tick virome composition and evolution. Herein, we employed RNA sequencing to study the virome diversity of the Haemaphysalis longicornis and Rhipicephalus microplus ticks sampled in Hubei Province in China. Twelve RNA viruses with complete genomes were identified, which belonged to six viral families: Flaviviridae, Matonaviridae, Peribunyaviridae, Nairoviridae, Phenuiviridae, and Rhabdoviridae. These viruses showed great diversity in their genome organization and evolution, four of which were proposed to be novel species. The virome diversity and abundance of R. microplus ticks fed on cattle were evidently high. Further ecological analyses suggested that host species and feeding status may be key factors affecting the tick virome structure. This study described a number of novel viral species and variants from ticks and, more importantly, provided insights into the ecological factors shaping the virome structures of ticks, although it clearly warrants further investigation.

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“…Segmented flaviviruses have recently been reported as emerging tick-borne viruses, with a wide distribution in Asia, Africa, Europe, Central America, and South America (44, 45). Of them, Jingmen tick virus (JMTV) and ALSV are associated with the febrile illness in tick-bitten patients in northeastern China.…”

Section: Discussionmentioning

confidence: 99%

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

Liu

Li²,

et al. 2022

Preprint

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Recently, several emerging tick-borne viruses have been identified to be associated with human diseases in northeastern China. Here, we used metagenomics to investigate the virome diversity in Haemaphysalis japonica, H. conicinna, Dermacentor silvarum, and Ixodes persulcatus ticks in northeastern China. A total of 22 RNA viruses were identified and belonged to more eight viral families, including four each in Nairoviridae and Phenuiviridae, three each in Flaviviridae, Rhabdoviridae, and Solemoviridae, two in Chuviridae, and one each in Partitiviridae, Tombusviridae, and unclassified. Of them, eight viruses were novel species, belonging to Nairoviridae (Ji’an nairovirus and Yichun nairovirus), Phenuiviridae (Mudanjiang phlebovirus), Rhabdoviridae (Tahe rhabdovirus 1-3), Chuviridae (Yichun mivirus), and Tombusviridae (Yichun tombus-like virus), and five members were established human pathogens, including Alongshan virus, tick-borne encephalitis virus, Songling virus, Beiji nairovirus, and Nuomin virus. I. persulcatus ticks had significant higher viral species than those in H. japonica, H. concinna, and D. silvarum ticks. Significant differences in tick viromes were observed among Daxingan, Xiaoxingan and Changbai mountains. These findings showed an extensive diversity of RNA viruses in ticks in northeastern China, revealed potential public health threats from the emerging tick-borne viruses. Further studies are needed to explain the natural circulation and pathogenicity of these viruses.

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Diversity and circulation of Jingmen tick virus in ticks and mammals

Cited by 41 publications

References 47 publications

Geographical and Tick-Dependent Distribution of Flavi-Like Alongshan and Yanggou Tick Viruses in Russia

Geographical and Tick-Dependent Distribution of Flavi-Like Alongshan and Yanggou Tick Viruses in Russia

Tick virome diversity in Hubei Province, China, and the influence of host ecology

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

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