Diversity and functions of intestinal mononuclear phagocytes

Joeris, Thorsten; Müller-Luda, K; Agace, William W.; Mowat, A M

doi:10.1038/mi.2017.22

Cited by 148 publications

(166 citation statements)

References 228 publications

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“…Intestinal dendritic cells can be classified into at least three distinct subsets based on their sole or combined expression of CD11b and CD103, as well as the dependence on either interferon regulatory factor 4 or 8 (IRF4 or IRF8) for their development and/or survival. 103 All three subsets are capable of processing antigens, migrating to mesenteric lymph nodes upon activation, and priming naive T cells. 103 Together, these studies demonstrate that specialized subsets of dendritic cells are responsible for the induction of distinct types of adaptive immunity.…”

Section: Inductionmentioning

confidence: 99%

“…103 All three subsets are capable of processing antigens, migrating to mesenteric lymph nodes upon activation, and priming naive T cells. 103 Together, these studies demonstrate that specialized subsets of dendritic cells are responsible for the induction of distinct types of adaptive immunity. Although the precise mechanisms behind this compartmentalization are unclear, they likely involve both cell-intrinsic signals and external factors that actively promote the generation of protective immunity and vice versa.…”

Section: Inductionmentioning

confidence: 99%

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Immunity to gastrointestinal nematode infections

2018

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Section: Inductionmentioning

confidence: 99%

Section: Inductionmentioning

confidence: 99%

Immunity to gastrointestinal nematode infections

2018

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“…23 In the intestine, macrophages recognize and remove enteric pathogens and maintain the balance necessary for the operation of the microbiota. 23,[26][27][28] The spleen contains macrophage lines derived to perform diverse functions. Splenic macrophages are responsible for phagocytizing senescent or altered erythrocytes, capturing antigens, and processing and presenting them to T lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

<p>Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases</p>

Sousa¹,

Vasconcelos²,

Quaresma³

2019

IDR

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Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of macrophage phenotypic heterogeneity has been investigated since the 1980s, and more recent studies have identified a diverse spectrum of phenotypic subpopulations. Several types of macrophages play a central role in the response to infectious agents and, along with other components of the immune system, determine the clinical outcome of major infectious diseases. Here, we review the functions of various macrophage phenotypic subpopulations, the concept of macrophage polarization, and the influence of these cells on the evolution of infections. In addition, we emphasize their role in the immune response in vivo and in situ, as well as the molecular effectors and signaling mechanisms used by these cells. Furthermore, we highlight the mechanisms of immune evasion triggered by infectious agents to counter the actions of macrophages and their consequences. Our aim here is to provide an overview of the role of macrophages in the pathogenesis of critical transmissible diseases and discuss how elucidation of this relationship could enhance our understanding of the host–pathogen association in organ-specific immune responses.

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“…Using Runx3-P1 AFP/+ or Runx3-P2 GFP/+ reporter mice established that in CD103 + CD11b + DC and in RM both promoters mediate Runx3 expression, however, P1 or P2 were preferentially used in these cells, respectively ( Figure S1C). Collectively, the results indicate that the known role of intestinal MNP in maintenance of GIT homeostasis (Joeris et al, 2017) is mediated, at least in part, by P1 and P2 driven Runx3 expression.…”

Section: Mice Lacking Runx3 In Colonic Mnp Develop Early Onset Spontamentioning

confidence: 77%

“…MNP are known for their role in maintaining GIT homeostasis (Joeris et al, 2017). In order to determine whether Runx3 expression in MNP plays role in GIT immune tolerance, we generated MNP-specific Runx3-cKO mice by crossing Runx3 fl/fl mice onto two different Cre transgenic strains, CD11c-Cre and Cx3cr1-Cre, generating Runx3 Δ and Cx3cr1-Runx3 Δ mice, respectively.…”

Section: Mice Lacking Runx3 In Colonic Mnp Develop Early Onset Spontamentioning

confidence: 99%

Runx3 prevents spontaneous colitis by directing differentiation of anti-inflammatory mononuclear phagocytes

Hantisteanu

Dicken

Negreanu

et al. 2019

Preprint

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RUNX3 is one of three mammalian Runt-domain transcription factors (TFs) that regulate gene expression in several types of immune cells. Runx3-deficiency in mice is associated with a multitude of defects in the adaptive and innate immunity systems, including the development of early onset colitis. Our study reveals that conditional deletion of Runx3 specifically in mononuclear phagocytes (MNP) (MNP Runx3-/-) but not in T cells, recapitulates the early onset spontaneous colitis seen in Runx3 -/mice.We show that Runx3 is expressed in colonic MNP, including resident macrophages (RM) and the dendritic cell cDC2 subsets and its loss results in impaired differentiation/maturation of both cell types. At the transcriptome level, loss of Runx3 in RM and cDC2 was associated with upregulation of pro-inflammatory genes similar to those in the early onset IBD murine model of RM Il10r-/-. The impaired RM maturation in the absence of Runx3 was associated with a marked decrease in expression of antiinflammatory and TGFb-regulated genes. Similarly, the decreased expression of b-

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Diversity and functions of intestinal mononuclear phagocytes

Cited by 148 publications

References 228 publications

Immunity to gastrointestinal nematode infections

Immunity to gastrointestinal nematode infections

<p>Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases</p>

Runx3 prevents spontaneous colitis by directing differentiation of anti-inflammatory mononuclear phagocytes

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