Diversity, Function and Regulation of Cell Surface and Intracellular Immune Receptors in Solanaceae

Kim, Jong Hum; Castroverde, Christian Danve M.

doi:10.3390/plants9040434

Cited by 9 publications

(4 citation statements)

References 190 publications

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“…Elevated temperatures target various components of the plant immune system (Velasquez et al, 2018; Cheng et al, 2019; Cohen and Leach, 2020; Kim et al, 2021), which encompass both cell surface (transmembrane) and intracellular immune receptors (Jones and Dangl, 2006; Zhou and Zhang, 2020; Kim and Castroverde, 2020; Ngou et al, 2022). Cell surface immune receptors recognize apoplastic immunogenic molecules, typically conserved pathogen-associated molecular patterns (PAMPs; Bigeard et al, 2015; Gust et al, 2017; DeFalco and Zipfel, 2021), while intracellular nucleotide-binding leucine-rich receptors (NLRs) perceive pathogen effectors and/or effector-induced host modifications (Cui et al, 2015; Jones et al, 2016; Saur et al, 2021).…”

Section: Main Textmentioning

confidence: 99%

Warm temperature suppresses plant systemic acquired resistance by intercepting theN-hydroxypipecolic acid immune pathway

Shields,

Yao,

Kim

et al. 2023

Preprint

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Climate warming influences disease development by targeting critical components of the plant immune system, including pattern-triggered immunity (PTI), effector-triggered immunity (ETI) and production of the central defence hormone salicylic acid (SA) at the primary pathogen infection site. However, it is not clear if and/or how temperature impacts systemic immunity. Here we show that pathogen-triggered systemic acquired resistance (SAR) inArabidopsis thalianais suppressed at elevated temperature. This was accompanied by global downregulation of SAR-induced genes at elevated temperature. Abolished SAR under warmer conditions was associated with reduced biosynthesis of the SAR metaboliteN-hydroxypipecolic acid (NHP) inArabidopsisand other plant species, as demonstrated by downregulation of NHP biosynthetic genes (ALD1andFMO1) and NHP precursor pipecolic acid (Pip) levels. Although multiple SAR signals have been shown previously, exogenous Pip was sufficient to restore disease protection at elevated temperature, indicating that heat-mediated SAR suppression is due to Pip-NHP downregulation. Along withALD1andFMO1, systemic expression of the SA biosynthetic geneICS1was also suppressed at warm temperature. Finally, we define a transcriptional network controlling thermosensitive NHP pathway via the master transcription factors CBP60g and SARD1. Our findings demonstrate that warm temperatures impact not only local but also systemic immunity by impinging on the NHP pathway, providing a roadmap towards engineering climate-resilient plant immune systems.

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Section: Main Textmentioning

confidence: 99%

Warm temperature suppresses plant systemic acquired resistance by intercepting theN-hydroxypipecolic acid immune pathway

Shields,

Yao,

Kim

et al. 2023

Preprint

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“…The other type of proteins is composed of intracellular receptors of the nucleotide-binding domain leucine-rich repeat protein superfamily (NLRs) (Jones, Vance & Dangl, 2016), which induces the effector-triggered immunity (ETI), which is often accompanied by hypersensitive response (HR) cell death. Together, these immune receptors act as a network of surveillance machines that recognize extracellular and intracellular pathogen invasion-derived molecules, ranging from conserved structural epitopes to virulence-promoting effectors (Kim & Castroverde, 2020).…”

Section: Avocado Immune Receptors Expression During F Kuroshium Interactions and In The Resistosomementioning

confidence: 99%

Molecular evidence of the avocado defense response to Fusarium kuroshium infection: a deep transcriptome analysis using RNA-Seq

Pérez-Torres

Ibarra-Laclette

Hernández-Domínguez

et al. 2021

PeerJ

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Fusarium kuroshium is a novel member of the Ambrosia Fusarium Clade (AFC) that has been recognized as one of the symbionts of the invasive Kuroshio shot hole borer, an Asian ambrosia beetle. This complex is considered the causal agent of Fusarium dieback, a disease that has severely threatened natural forests, landscape trees, and avocado orchards in the last 8 years. Despite the interest in this species, the molecular responses of both the host and F. kuroshium during the infection process and disease establishment remain unknown. In this work, we established an in vitro pathosystem using Hass avocado stems inoculated with F. kuroshium to investigate differential gene expression at 1, 4, 7 and 14 days post-inoculation. RNA-seq technology allowed us to obtain data from both the plant and the fungus, and the sequences obtained from both organisms were analyzed independently. The pathosystem established was able to mimic Fusarium dieback symptoms, such as carbohydrate exudation, necrosis, and vascular tissue discoloration. The results provide interesting evidence regarding the genes that may play roles in the avocado defense response to Fusarium dieback disease. The avocado data set comprised a coding sequence collection of 51,379 UniGenes, from which 2,403 (4.67%) were identified as differentially expressed. The global expression analysis showed that F. kuroshium responsive UniGenes can be clustered into six groups according to their expression profiles. The biologically relevant functional categories that were identified included photosynthesis as well as responses to stress, hormones, abscisic acid, and water deprivation. Additionally, processes such as oxidation-reduction, organization and biogenesis of the cell wall and polysaccharide metabolism were detected. Moreover, we identified orthologues of nucleotide-binding leucine-rich receptors, and their possible action mode was analyzed. In F. kuroshium, we identified 57 differentially expressed genes. Interestingly, the alcohol metabolic process biological category had the highest number of upregulated genes, and the enzyme group in this category may play an important role in the mechanisms of secondary metabolite detoxification. Hydrolytic enzymes, such as endoglucanases and a pectate lyase, were also identified, as well as some proteases. In conclusion, our research was conducted mainly to explain how the vascular tissue of a recognized host of the ambrosia complex responds during F. kuroshium infection since Fusarium dieback is an ambrosia beetle-vectored disease and many variables facilitate its establishment.

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“…Plants rely on their two-tiered and interlinked innate immune system to initiate local responses against pathogenic attack ( Jones and Dangl, 2006 ; Kim and Castroverde, 2020 ; Zhou and Zhang, 2020 ; Yuan et al, 2021 ). First, pattern-triggered immunity (PTI) is initiated after activation of cell surface pattern recognition receptors (PRRs) that typically recognize conserved pathogen-associated molecular patterns (PAMPs; Macho and Zipfel, 2014 ; Li et al, 2016 ; DeFalco and Zipfel, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Salicylic Acid and N-Hydroxypipecolic Acid at the Fulcrum of the Plant Immunity-Growth Equilibrium

2022

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Salicylic acid (SA) and N-hydroxypipecolic acid (NHP) are two central plant immune signals involved in both resistance at local sites of pathogen infection (basal resistance) and at distal uninfected sites after primary infection (systemic acquired resistance). Major discoveries and advances have led to deeper understanding of their biosynthesis and signaling during plant defense responses. In addition to their well-defined roles in immunity, recent research is emerging on their direct mechanistic impacts on plant growth and development. In this review, we will first provide an overview of how SA and NHP regulate local and systemic immune responses in plants. We will emphasize how these two signals are mutually potentiated and are convergent on multiple aspects—from biosynthesis to homeostasis, and from signaling to gene expression and phenotypic responses. We will then highlight how SA and NHP are emerging to be crucial regulators of the growth-defense balance, showcasing recent multi-faceted studies on their metabolism, receptor signaling and direct growth/development-related host targets. Overall, this article reflects current advances and provides future outlooks on SA/NHP biology and their functional significance as central signals for plant immunity and growth. Because global climate change will increasingly influence plant health and resilience, it is paramount to fundamentally understand how these two tightly linked plant signals are at the nexus of the growth-defense balance.

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Diversity, Function and Regulation of Cell Surface and Intracellular Immune Receptors in Solanaceae

Cited by 9 publications

References 190 publications

Warm temperature suppresses plant systemic acquired resistance by intercepting theN-hydroxypipecolic acid immune pathway

Warm temperature suppresses plant systemic acquired resistance by intercepting theN-hydroxypipecolic acid immune pathway

Molecular evidence of the avocado defense response to Fusarium kuroshium infection: a deep transcriptome analysis using RNA-Seq

Salicylic Acid and N-Hydroxypipecolic Acid at the Fulcrum of the Plant Immunity-Growth Equilibrium

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