Diversity of Antibiotic-Active Bacteria Associated with the Brown Alga Laminaria saccharina from the Baltic Sea

Wiese, Jutta; Thiel, Vera; Nagel, Kerstin; Staufenberger, Tim; Imhoff, Johannes F.

doi:10.1007/s10126-008-9143-4

Cited by 155 publications

(107 citation statements)

References 66 publications

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“…Of the 210 bacterial isolates from the brown alga Laminaria saccharina, 103 inhibited the growth of at least 1 of the pathogens tested (Wiese et al 2009). By contrast, out of 92 isolates from Japanese red algae, only ca one-third of the isolates inhibited the growth of environmental and pathogenic bacteria (Kanagasabhapathy & Nagata 2008).…”

Section: Antibacterial Activity Heterotrophic Bacteriamentioning

confidence: 99%

Mini-review: Inhibition of biofouling by marine microorganisms

2013

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Any natural or artificial substratum exposed to seawater is quickly fouled by marine microorganisms and later by macrofouling species. Microfouling organisms on the surface of a substratum form heterogenic biofilms, which are composed of multiple species of heterotrophic bacteria, cyanobacteria, diatoms, protozoa and fungi. Biofilms on artificial structures create serious problems for industries worldwide, with effects including an increase in drag force and metal corrosion as well as a reduction in heat transfer efficiency. Additionally, microorganisms produce chemical compounds that may induce or inhibit settlement and growth of other fouling organisms. Since the last review by the first author on inhibition of biofouling by marine microbes in 2006, significant progress has been made in the field. Several antimicrobial, antialgal and antilarval compounds have been isolated from heterotrophic marine bacteria, cyanobacteria and fungi. Some of these compounds have multiple bioactivities. Microorganisms are able to disrupt biofilms by inhibition of bacterial signalling and production of enzymes that degrade bacterial signals and polymers. Epibiotic microorganisms associated with marine algae and invertebrates have a high antifouling (AF) potential, which can be used to solve biofouling problems in industry. However, more information about the production of AF compounds by marine microorganisms in situ and their mechanisms of action needs to be obtained. This review focuses on the AF activity of marine heterotrophic bacteria, cyanobacteria and fungi and covers publications from 2006 up to the end of 2012.

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Section: Antibacterial Activity Heterotrophic Bacteriamentioning

confidence: 99%

Mini-review: Inhibition of biofouling by marine microorganisms

2013

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“…These bacteria have been especially well studied from terrestrial habitats [45,46], but have also been reported from marine habitats. Rhizobiales are common epiphytes of Ulva seaweeds [47][48][49][50] and have also been isolated from the surface of kelps where they display antimicrobial activity [13]. Additionally, a Rhodopseudomonas species with the potential to fix nitrogen was isolated from the rhizoidal cytoplasm of the siphonous green seaweed Caulerpa taxifolia [19].…”

Section: (A) Diversity Of Endogenous Bacteriamentioning

confidence: 99%

“…compounds [12][13][14]. Siphonous green seaweeds, belonging to the Bryopsidales and Dasycladales of the chlorophytan class Ulvophyceae, consist of a single giant tubular cell and form a benevolent biotic environment for endobiotic bacterial communities [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Permanent residents or temporary lodgers: characterizing intracellular bacterial communities in the siphonous green algaBryopsis

et al. 2013

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The ecological success of giant celled, siphonous green algae in coastal habitats has repeatedly been linked to endophytic bacteria living within the cytoplasm of the hosts. Yet, very little is known about the relative importance of evolutionary and ecological factors controlling the intracellular bacterial flora of these seaweeds. Using the marine alga Bryopsis (Bryopsidales, Chlorophyta) as a model, we explore the diversity of the intracellular bacterial communities and investigate whether their composition is controlled by ecological and biogeographic factors rather than the evolutionary history of the host. Using a combination of 16S rDNA clone libraries and denaturing gradient gel electrophoresis analyses, we show that Bryopsis harbours a mixture of relatively few but phylogenetically diverse bacterial species. Variation partitioning analyses show a strong impact of local environmental factors on the presence of Rickettsia and Mycoplasma in their association with Bryopsis. The presence of Flavobacteriaceae and Bacteroidetes, on the other hand, reflects a predominant imprint of host evolutionary history, suggesting that these bacteria are more specialized in their association. The results highlight the importance of interpreting the presence of individual bacterial phylotypes in the light of ecological and evolutionary principles such as phylogenetic niche conservatism to understand complex endobiotic communities and the parameters shaping them.

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“…10 Strain NTK 935 was examined using a combination of genotypic and phenotypic procedures known to produce data of value in the delineation of Streptomyces species. 15 Extraction of the DNA, amplification of the 16S rRNA gene sequence, as well as the sequencing procedure, were performed according to Wiese et al 16 The 16S rRNA sequence of strain NTK 935 was edited using BioEdit (http:// www.mbio.ncsu.edu/BioEdit/bioedit.html). The Ribosomal Database Project database (http://rdp.cme.msu.edu) was used to select the most clearly related type strains.…”

Section: Producing Organism and Its Classificationmentioning

confidence: 99%

Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935

et al. 2011

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Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3b and a weak antiproliferative activity against mouse fibroblast cells. Keywords: 1,4-benzoxazin-3-one; glycogen synthase kinase 3b; marine Streptomyces INTRODUCTION Actinomycetes from marine sediments collected at various sites in the Atlantic and Pacific Oceans were screened by HPLC-diode array analysis for the production of novel secondary metabolites. Strain NTK 935 was isolated from the same deep-sea sediment core as Streptomyces sp. NTK 937, which we reported recently to produce caboxamycin, a novel antibiotic with a benzoxazole scaffold. 2 Extracts of strain NTK 935 contained a metabolite having an unusual UV-vis spectrum, which was not identified by means of our in-house developed HPLC database. 3 HPLC-ESI-MS analysis revealed a molecular mass of 380, which was-together with UV-vis data-not in accordance with other natural products available in the DNP database. 4 Therefore, strain NTK 935 was selected for fermentation studies, isolation and characterization of the unusual metabolite; this resulted in the identification of the novel 1,4-benzoxazine structure shown in Figure 1.This study describes the taxonomy of the producing strain, fermentation and isolation, structural elucidation and biological activity of the new benzoxazine-type metabolite, which was named benzoxacystol.

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Diversity of Antibiotic-Active Bacteria Associated with the Brown Alga Laminaria saccharina from the Baltic Sea

Cited by 155 publications

References 66 publications

Mini-review: Inhibition of biofouling by marine microorganisms

Mini-review: Inhibition of biofouling by marine microorganisms

Permanent residents or temporary lodgers: characterizing intracellular bacterial communities in the siphonous green algaBryopsis

Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935

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