Diversity of Antisperm Antibodies Bound to Sperm Surface in Male Immunological Infertility

Shibahara, Hiroaki; Tsunoda, Tetsuo; Taneichi, Akiyo; Hirano, Yuki; Ohno, Akiko; Takamizawa, Satoru; Yamaguchi, Chieko; Tsunoda, Hiromichi; Sato, Ikuo

doi:10.1034/j.1600-0897.2002.1o059.x

Cited by 27 publications

(21 citation statements)

References 34 publications

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“…Note that IgD and IgE isotypes are practically nonexistent in seminal fluid [24]. Compared to Shibahara et al [23], we found a lower incidence rates in the retrospective study but similar values in A. Laudat, L. Burc-Struxiano 7/11 OALib Journal the prospective study (with an increase in IgA-class antisperm antibody). The presence of immunoglobulins bound to different sections of spermatozoa has numerous repercussions on fertility.…”

Section: Discussionsupporting

confidence: 71%

“…Human antisperm autoimmunity appears to involve three classes of immunoglobulins. A study by Shibahara et al in 275 infertile men reported the following isotype-stratified incidence rates: 2.5% for IgG, 1.8% for IgA and 0.4% for IgM [23]. Note that IgD and IgE isotypes are practically nonexistent in seminal fluid [24].…”

Section: Discussionmentioning

confidence: 96%

“…In males, then, the relationship between sperm antibodies and immunological subfertility is complex to grasp. There is effectively an interplay of 3 components, each co-embedded to varying degrees, to factor in: 1) substantial heterogeneity in human sperm antigens, 2) the existence of different autoantibody classes (where IgA may be stronger drivers of subfertility) and 3) which part(s) of the spermatozoa anatomy theantibodies are bound to [23]. When coverslipping an ejaculate after liquefaction for 1 hour at 37˚C, the big two signs pointing to antisperm autoimmunity are: presence of sperm agglutinates (clumps of live spermatozoa) in the sample (Figure 1) and asthenozoospermia (reduced number of motile forms) [7] [8] [9] [18].…”

Section: Discussionmentioning

confidence: 99%

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Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?

Laudat¹,

Burc-Struxiano²

2016

OALib

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Objective: Here we compared the results of a prospective study systematically screening for antisperm antibodies in a cohort of subfertile males to the results of a previous retrospective study in equally subfertile patients where screening for antisperm antibodies was performed solely if semen presented spontaneous agglutinates of sperm. Methods: The prospective study was conducted on 317 semen analyses between 1 September 2014 and 9 December 2015 and the retrospective study investigated 2823 semen analyses performed between 1 April 2004 and 31 March 2014. Sperm parameter analysis used exactly the same techniques across patients in both studies. Screening for IgG and IgA class antisperm antibodies was performed by using the direct (in-semen) MAR test with immunobeads. Results: Retrospectively, 76 (2.69%) of the 2823 patients in the cohort had a positive MAR test after presenting semen showing sperm agglutination. Compared to this group, the prospective study found a significantly higher number of patients presenting antisperm antibodies (positive MAR test in 25 patients, i.e. 7.88%). Of these 25 patients, IgA and mixed (IgG and IgA) class antisperm antibodies were significantly higher in the prospective group than those in the retrospective group. Conclusion: Given how antisperm antibodies can damagingly block or hamper different prefertilization and possibly postfertilization events, screening for antisperm antibodies solely on the basis of sperm agglutinates does not look adequate. This study advocates making screening for autoimmunity to sperm a routine part of the basic workup for male subfertility.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?

Laudat¹,

Burc-Struxiano²

2016

OALib

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“…Indeed, there is a need to examine the entry of other classes of antibody into the lumen of the reproductive ducts. For example, IgA and IgM as well as IgG have been found in human and boar semen [54,55], and in humans, prostatic fluid contains IgG [56] and the prostate gland secretes IgA [57][58][59][60]. It is possible that sufficient IgA may be secreted into accessory gland fluids for this purpose so that it is worthwhile examining mucosal as well as systemic immunization to raise the immune response.…”

Section: Discussionmentioning

confidence: 99%

Transport of IgG across the Blood-Luminal Barrier of the Male Reproductive Tract of the Rat and the Effect of Estradiol Administration on Reabsorption of Fluid and IgG by the Epididymal Ducts1

Knee

Hickey

Beagley

et al. 2005

Biology of Reproduction

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In rats immunized systemically with tetanus toxoid the concentration of specific anti-tetanus-toxoid-specific IgG in fluid from the rete testis and cauda epididymidis were respectively 0.6% and 1.4% the concentration in blood serum. The extratesticular duct system reabsorbed 97% of the IgG and 99% of the fluid leaving the rete, but estradiol administration affected the site of reabsorption. In untreated rats, the ductuli efferentes reabsorbed 94% of the IgG and 96% of the fluid leaving the rete, whereas estradiol-treated rats reabsorbed 83% of the IgG and 86% of the fluid, and the ductus epididymidis fully compensated for these different effects of estradiol on the ductuli efferentes. The concentrations of IgG in secretions of the seminal vesicles and prostate gland were lower (0.1% and 0.3% respectively of the titers in blood serum) than in fluids from the extratesticular ducts, and were not affected by the administration of estradiol. RT-PCR showed that Fcgrt (neonatal Fc receptor, also known as FcRn) is expressed in the reproductive ducts, where IgG is probably transported across epithelium, being particularly strong in the ductuli efferentes (where most IgG was reabsorbed) and distal caput epididymidis. It is concluded that IgG enters the rete testis and is concentrated only 2.5-fold along the extratesticular duct system, unlike spermatozoa, which are concentrated 95-fold. Further, the ductus epididymidis can recognize and compensate for changes in function of the ductuli efferentes.

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“…As for ASAs themselves, there is also diversity such as Ig classes of ASAs (22), the localization of the corresponding antigens against ASAs, and the biologic activity of ASAs bound to sperm surface in males (23). In some cases, it has been shown that ASAs bound to the sperm surface are sperm immobilizing antibodies; others were not (24).…”

Section: Discussionmentioning

confidence: 96%

In vitro and in vivo studies evaluating antisemen antibodies as a potential spermicidal agent in hamsters

Chen

Liu

Xie

et al. 2009

Fertility and Sterility

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Diversity of Antisperm Antibodies Bound to Sperm Surface in Male Immunological Infertility

Cited by 27 publications

References 34 publications

Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?

Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?

Transport of IgG across the Blood-Luminal Barrier of the Male Reproductive Tract of the Rat and the Effect of Estradiol Administration on Reabsorption of Fluid and IgG by the Epididymal Ducts1

In vitro and in vivo studies evaluating antisemen antibodies as a potential spermicidal agent in hamsters

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