Handbook of Immunosenescence 2019
DOI: 10.1007/978-3-319-99375-1_87
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Diversity of CD28null T Cells in the Elderly: A Glimpse in a Biological Adaptation of Aging

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“…Besides, costimulatory molecule CD28 expression decreases and telomere shortening is observed in senescent T-cells [ 67 ]. CD28 loss is characterized by inability of senescent T-cells to proliferate due to decreased telomerase activity, and nonspecific cytotoxicity in a manner like Natural Killer (NK) cells via recognition of NK-Cell receptors [ 68 ]. Therefore, senescent T lymphocyte repertoire is already disadvantageous in dealing with SARS-CoV-2 [ 25 ].…”
Section: Altered Immunity In Older Adults and Covid-19mentioning
confidence: 99%
“…Besides, costimulatory molecule CD28 expression decreases and telomere shortening is observed in senescent T-cells [ 67 ]. CD28 loss is characterized by inability of senescent T-cells to proliferate due to decreased telomerase activity, and nonspecific cytotoxicity in a manner like Natural Killer (NK) cells via recognition of NK-Cell receptors [ 68 ]. Therefore, senescent T lymphocyte repertoire is already disadvantageous in dealing with SARS-CoV-2 [ 25 ].…”
Section: Altered Immunity In Older Adults and Covid-19mentioning
confidence: 99%