Diversity of compounds in Vespa spp. venom and the epidemiology of its sting: a global appraisal

Herrera, Cayetano; Leza, Mar; Martínez-López, Emma

doi:10.1007/s00204-020-02859-3

Cited by 21 publications

(13 citation statements)

References 118 publications

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“…En los véspidos, esto se suma al hecho de que las colonias se encuentran protegidas físicamente por el nido, que en V. velutina es ubicado con frecuencia en la copa de los árboles limitando el acceso a aquellos predadores capaces de llegar allí. Además, las hembras tienen un aguijón de 6 mm de longitud con el cual inyecta un veneno rico en toxinas y otros compuestos (Herrera et al 2020). A pesar de estas contundentes defensas, las larvas y adultos de V. velutina tienen predadores en las áreas invadidas (Monceau et al 2014a).…”

Section: Defensa Contra Predadoresunclassified

“…5). Se ha identificado una compleja composición de péptidos de bajo peso molecular, proteínas de alto peso molecular y otros componentes que actúan como enzimas, toxinas y alérgenos en los componentes del veneno V. velutina (Herrera et al 2020). Actualmente hay avances en el entendimiento de las rutas a través de las cuales estos animales afectan a la salud de las personas permitiendo el desarrollo de tratamientos médicos apropiados (Monsalve et al 2020).…”

Section: Impactos Socialesunclassified

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Vespa velutina: traits and impacts of a successful invasive alien species

Rojas‐Nossa

Gil²,

Mato

et al. 2021

ECOS

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La invasión de Vespa velutina Lepeletier, 1836 experimenta un avance en la expansión a nuevas áreas y es, a día de hoy, una especie exótica invasora que genera alarma social y preocupación por sus impactos ecológicos, económicos y sociales. El objetivo de este trabajo es explorar los caracteres biológicos de la especie para entender la raíz de su éxito invasor y los impactos que genera. Estos se relacionan con aspectos tales como un complejo sistema social, un versátil comportamiento generalista o una alta tasa reproductiva sumada a la capacidad de establecer colonias a partir de una sola reina fecundada. Los impactos de este himenóptero sobre los ecosistemas y la apicultura se relacionan con su comportamiento como predador de insectos polinizadores, en particular de abejas de la miel. El incremento de la población durante el verano y su preferencia por las áreas urbanas y semiurbanas implican encuentros frecuentes con las personas, que a menudo sufren picaduras. Sus defensas involucran la comunicación química que desencadena ataques colectivos y la inyección de un veneno rico en toxinas que impacta la salud humana.

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Section: Defensa Contra Predadoresunclassified

Section: Impactos Socialesunclassified

Vespa velutina: traits and impacts of a successful invasive alien species

Rojas‐Nossa

Gil²,

Mato

et al. 2021

ECOS

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“…V. velutina stings cause reactions by injecting venom via their ovipositors into their target [11]. Wasps and hornets mainly have three groups of components in their venom: small molecular weight peptides, high molecular weight proteins and other components that act as enzymes, toxins and allergens [1]. Hyaluronidases are enzymes that hydrolyze hyaluronan in human skin to increase tissue permeability to fluids.…”

Section: Molecular Dockingmentioning

confidence: 99%

“…This "killer" hornet has been identified in the Vespa genus that is spread worldwide. One of the species is Vespa velutina, or commonly known as the Yellow-legged hornet, is a hornet species native to Asia with a distribution area in Indonesia and is known as an aggressive species [1]. V. velutina often builds nests in residential areas, where humans can attack.…”

Section: Introductionmentioning

confidence: 99%

Virtual Screening of Mimosa pudica Secondary Metabolites as Hyaluronidase B Potential Inhibitor to Prevent Vespa velutina Venom Spreading

et al. 2021

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Vespa velutina, also known as the Yellow-legged hornet, is a wasp species native to Asia with a large distribution area in Indonesia. Hyaluronidase B in a wasp venom acts as a "spreading factor", which is the key at the beginning of envenomation. Shameplant (Mimosa pudica), a common plant in Indonesia, has shown the potential to be a hyaluronidase B inhibitor. This study aimed to analyze the potential of secondary metabolites in Shameplant as an inhibitor of V. velutina Hyaluronidase B base on their molecular interactions and as a topical drug base on physicochemical characteristics. In silico computational studies is performed to predict the binding modes of M. pudica compounds and hyaluronidase B enzyme. The secondary metabolites were retrieved from the PubChem database and screened using SwissADME. The seven metabolite compounds were docked with Hyaluronidase B and hyaluronan by HEX Cuda 8.0.0 program. Hyaluronidase B was also docked with its native ligand (hyaluronan) to validate the docking study. Three dimensional and 2D views were then evaluated using Discovery Studio 2016. Results of this study are all compounds do not have the same molecular interaction with the control. It defines no inhibition of the interaction on the active side. Mimopudine is the most potent inhibitor of hyaluronidase B based on its binding energy. While, jasmonic acid is the only compound that meets the physicochemical parameter of the topical drug.

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“…In the last years, health risks and deaths caused by Hymenopteran stings have become a worldwide public health concern [15,16]. Despite the number of cases presented, this health problem can be underestimated.…”

Section: Introductionmentioning

confidence: 99%

What We Know About Sting-Related Deaths? Human Fatalities Caused by Hornet, Wasp and Bee Stings in Europe (1994-2016)

Feás¹,

Vidal²,

Remesar³

2021

Preprint

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Epidemiology of Hymenopteran-related deaths in Europe due to bee, wasp and hornet stings (Cause Code of Death: X23) based on official registers from WHO Mortality Database is described. Over a 23-year period (1994-2016), a total of 1,691 fatalities were officially recorded, mostly occurring in Western (42.8%) and Eastern (31.9%) Europe. The victims tended to concentrate in: Germany (n=327; 1998-2015), France (n=211; 2000-2014) and Romania (n=149; 1999-2016). The majority of deaths occurred in males (78.1%), within the age group of 25-64 years (66.7%), and in an “unspecified place” (44.2%). The X23 gender ratio (X23GR) of mortality varied from a minimum of 1.4 for Norway to a maximum of 20 for Slovenia. The highest X23MR, expressed in terms of annual rates and per million inhabitants, were recorded in countries from Eastern Europe (0.35) followed by Western (0.28), Northern (0.23) and Southern Europe (0.2). The countries with the highest and lowest mean X23MR were Estonia (0.61), Austria (0.6) and Slovenia (0.55); and Ireland (0.05), United Kingdom (0.06) and the Netherlands (0.06), respectively. Country-by-country data show that the incidence of insect-sting mortality is statistically low, but not negligible.

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Diversity of compounds in Vespa spp. venom and the epidemiology of its sting: a global appraisal

Cited by 21 publications

References 118 publications

Vespa velutina: traits and impacts of a successful invasive alien species

Vespa velutina: traits and impacts of a successful invasive alien species

Virtual Screening of Mimosa pudica Secondary Metabolites as Hyaluronidase B Potential Inhibitor to Prevent Vespa velutina Venom Spreading

What We Know About Sting-Related Deaths? Human Fatalities Caused by Hornet, Wasp and Bee Stings in Europe (1994-2016)

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