Diversity of coronary arterial tree in laboratory mice

Abstract

Background: Research on the development and topography of mouse coronary arteries has been conducted for many years. Patterns of the course of these vessels have been described in various mouse strains. Our research focused on hearts of MIZZ mice. Materials and methods: We visualised the coronary artery system by means of latex dye perfusion via the aorta. The injected latex did not reach the capillary vessel system. Results: The heart of MIZZ mice is supplied with blood by two main coronary arteries: the right and the left one. They deliver blood to the right and left part of the heart, respectively. The right coronary artery arises from the right sinus of the aorta and the left coronary artery from the left sinus. The interventricular septum is usually supplied by the septal artery, which is the main branch of the right coronary artery. All arteries of the coronary system run intramurally. The number of branches and the location of their ostia differed among the examined individuals. Conclusions: Detailed information about the normal topography of coronary arteries, the number and course of their branches, as well as the area of the heart which is vascularised by these vessels constitutes the basic knowledge necessary to conduct further experiments.

A new corrosion method (Aycan’s method)

“…In known corrosion methods, the prepared corrosion fluid is injected into the vessels of the organs with positive pressure [1][2][3][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In this study, instead of positive pressure, negative pressure was applied to the organs, allowing corrosion fluid to enter the vessels.…”

“…The distribution of vessels within organs or the internal structure of organs has been investigated by anatomists for years. For this purpose, radiological methods or plastic injection corrosion methods are used [1][2][3][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In the corrosion method, liquid solutions of substances with solidification properties (Polyester, Nylon, Latex, polyvinyl chloride or Mercox CL-2R, methyl methacrylate, vinyl resin) are prepared [1,7,11,14,19].…”

“…This method is called the corrosion method. With this method, the anatomy of the circulation within the organs is examined [1][2][3][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The corrosion method has been used for years.…”

Increased Remnant Lipoproteins in Apo E Deficient Mice Induce Coronary Atherosclerosis following Transverse Aortic Constriction and Aggravate the Development of Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

“…In species with intramyocardial coronary arteries, the interventricular septum is mainly irrigated by a distinct artery, the septal artery [ 37 ]. A single major septal coronary artery in mice may arise either from a separate ostium from the right sinus of Valsalva or originate as a proximal branch of the right coronary artery or less frequently from the left coronary artery [ 37 , 38 , 39 ]. Occasionally two septal arteries are present [ 37 , 38 ].…”