Diversity of Cytokine Synthesis and Function of Mouse CD4<sup>+</sup> T Cells

Mosmann, Tim R.; Schumacher, J H; Street, N. F.; Budd, Ralph C.; O’Garra, Anne; Fong, Tsorng Harn; Bond, Michael D.; Moore, Kevin W.; Sher, Alan; Fiorentino, David

doi:10.1111/j.1600-065x.1991.tb00612.x

Cited by 369 publications

(177 citation statements)

References 51 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…Later, new cytokines were identified and were classified as T hl for TNF/3 and as Th2 for IL-6, IL-10, and IL-13. Simulta neously, a precursor (ThO) subset that produced IL-4, IL-2, and IFNy was described (11). These precursor cells are themselves derived from virgin T cells (Thp), which secrete IL-2 following activation.…”

Section: Thl/th2 Cytokine Balance From Mice To Humansmentioning

confidence: 99%

The Th1/Th2 cytokine balance in arthritis

Gruber¹,

Wagner²,

Block

1998

T Cells in Arthritis

View full text Add to dashboard Cite

Section: Thl/th2 Cytokine Balance From Mice To Humansmentioning

confidence: 99%

The Th1/Th2 cytokine balance in arthritis

Gruber¹,

Wagner²,

Block

1998

T Cells in Arthritis

View full text Add to dashboard Cite

“…First characterized were subsets of CD4 π T helper (Th) cells, the most polarized forms of which (designated Th1 and Th2 cells) have been shown to differ with respect to cytokine secretion patterns (6,7). More recently, a similar heterogeneity among CD8 π T cytotoxic (Tc) cells has been recognized also, with the identification of Tc1 and Tc2 subpopulations (8,9).…”

mentioning

confidence: 99%

Allergic contact dermatitis: the cellular effectors

2002

View full text Add to dashboard Cite

Contact hypersensitivity reactions are mediated by lymphocytic effector cells. Until recently it was believed that the most important of these were CD4 π T lymphocytes. However, there is growing evidence that in many instances the predominant effector cell may be a CD8 π T lymphocyte, with in some instances CD4 π cells performing a counter-regulatory function. Here we review the roles of CD4 π T helper (Th) cells and CD8 π T cytotoxic (Tc) cells, and their main functional subpopulations (respectively, Th1 and Th2 cells and Tc1 and Tc2 cells) in the elicitation of contact hypersensitivity reactions and consider the implications of effector cell selectivity for the biology of allergic contact dermatitis.

show abstract

“…Thl cells produce interleukin-2 (IL-2), gamma interferon, and lymphotoxin and promote cell-mediated immunity for elimination of viruses and intracellular parasites (38,43,47). In contrast, Th2 cells secrete IL-4, IL-5, IL-6, and IL-10 and promote humoral immunity against extracellular pathogens through activation of B cells and regulation of isotype switching (16,38).…”

mentioning

confidence: 99%

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993

View full text Add to dashboard Cite

Activity of the murine interleukin-4 (ILH4) promoter was localized to several cis-acting elements present within the first 300 bp from the transcriptional initiation site. Five repeated elements, P0 to P4, that share the common consensus ATTITCCNNT were located between -40 and -250, and each was shown to interact with the T-cell-specific factor NF(P). These distinct P sites appear functionally interchangeable and cooperatively confer cyclosporin A-sensitive and ionomycin-inducible promoter activity. NF(P)

show abstract

Diversity of Cytokine Synthesis and Function of Mouse CD4⁺ T Cells

Cited by 369 publications

References 51 publications

The Th1/Th2 cytokine balance in arthritis

The Th1/Th2 cytokine balance in arthritis

Allergic contact dermatitis: the cellular effectors

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

Contact Info

Product

Resources

About

Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells

Cited by 369 publications

References 51 publications

The Th1/Th2 cytokine balance in arthritis

The Th1/Th2 cytokine balance in arthritis

Allergic contact dermatitis: the cellular effectors

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

Contact Info

Product

Resources

About

Diversity of Cytokine Synthesis and Function of Mouse CD4⁺ T Cells