Diversity of daily activities is associated with greater hippocampal volume

Urban-Wojcik, Emily; Lee, Soomi; Grupe, Daniel W.; Quinlan, Laurel; Gresham, Lauren K.; Hammond, Angel; Charles, Susan T.; Lachman, Margie E.; Almeida, David M.; Davidson, Richard J.; Schaefer, Stacey M.

doi:10.3758/s13415-021-00942-5

Cited by 23 publications

(19 citation statements)

References 57 publications

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“…An enriched and complex environment has been shown to maintain cognitive abilities in older age (Schooler, 1984; Stine-Morrow et al, 2014). More importantly, Urban-Wojcik et al (2022) showed that greater activity diversity was associated with larger hippocampal volume, which in turn indicates past experiences with enriched environmental stimulation. Furthermore, diverse activities have also been seen as an indication of a high degree of integration in social relations (Lee et al, 2021).…”

Section: Activity Diversity and Cognitive Abilities In Older Agementioning

confidence: 93%

“…Similar to previous studies on activity diversity and cognitive abilities (Lee et al, 2021; Urban-Wojcik et al, 2022), we controlled for participants’ gender and a number of health conditions. We also controlled for marital status, retirement status, typical level of activity diversity, and daily activity frequency to ensure any relationship between daily activity diversity and daily working memory was not driven by an overall status of having social company and a busier schedule.…”

Section: Activity Diversity and Cognitive Abilities In Older Agementioning

confidence: 99%

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Daily activity diversity and daily working memory in community-dwelling older adults.

et al. 2023

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Objective: Cross-sectional and long-term longitudinal studies have shown that engagement in diverse activities benefits cognitive performance in older age, but it is unknown whether the beneficial effect holds within persons on a daily basis. This study examines the within-person association between activity diversity and working memory on the same day and its time-lagged directionality between days. It also examines the effects of potential moderators on the within-person association, including age, education, processing speed, and crystallized intelligence, to understand who may benefit more from daily activity diversity. Method: We examined smartphone-based ambulatory assessment data from 150 community-dwelling older adults (aged 65–91 years) from Switzerland. Participants reported their present activity and completed a working memory task (i.e., numerical updating) seven times per day over 15 days. Activity diversity was calculated on a daily level and scores of working memory were averaged within a day. Age, education, processing speed, and crystallized intelligence were assessed in the laboratory at baseline. Results: Multilevel models showed that, within persons, higher daily activity diversity was positively associated with higher daily working memory. Moreover, the prior day’s greater activity diversity led to that day’s higher working memory, but not vice versa. There were no moderating effects of age, education, and crystallized intelligence, but partial evidence of a moderating effect of processing speed. Conclusions: Our results on within-person concurrent and time-lagged associations between daily activity diversity and daily working memory strengthen the existing evidence on the beneficial effect of activity diversity on older adults’ cognitive performance. Results are discussed in the context of cognitive reserve theory.

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Section: Activity Diversity and Cognitive Abilities In Older Agementioning

confidence: 93%

Section: Activity Diversity and Cognitive Abilities In Older Agementioning

confidence: 99%

Daily activity diversity and daily working memory in community-dwelling older adults.

et al. 2023

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“…Detected events were further processed and filtered with a low-pass filter (1-100 Hz) for LFPs, and a band-pass filter (300-3500 Hz) for MUAs, and a band-pass filter (140 -220 Hz) for ripples. Additionally, LFP waveforms were bandpass filtered using 4 th order Butterworth filter at delta (1-4 Hz), theta (5)(6)(7)(8)(9)(10)(11)(12), beta , and gamma (35-100) bands.…”

Section: Methodsmentioning

confidence: 99%

“…This lack of direct evidence at the circuit level is partly explained by the historical lack of applicable methodology. Broad-scale electrophysiology has been impossible and non-invasive MRI in humans suggests that enrichment has generalizing network effects 5 does not have sufficient resolution to study particular brain networks in rodents 6 . The hippocampal network plays a central role in spatial, contextual, and episodic memory, as well as effective behaviors, and the hippocampus is sensitive to environmental influences that result in functional changes in these domains 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Rich Experience Boosts Functional Connectome and High-Dimensional Coding in Hippocampal Network

Emery

Khanzada

et al. 2022

Preprint

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Challenging the brain with experiential richness creates tissue-level changes and synaptic plasticity, but the interjacent network level has not been accessible. We here show that environmental enrichment has unexpectedly far-reaching effects on network connectivity and multi-dimensional coding in the hippocampus. We present direct evidence that experience impacts local and global network connectivity, synchrony, and rhythmic dynamics. For this, we investigated the hippocampi from standard-housed mice (SD) and mice living in an enriched environment (ENR) using large-scale ex vivo recordings with a high-density microelectrode sensing array that with the unprecedented spatiotemporal resolution allowed simultaneous electrophysiological assessment across the entire circuit. In the absence of extrinsic electrical network stimulation, we found enhanced functional connectivity and high-dimensional coding in hippocampal-cortical networks of ENR mice. The mapped connectome illustrated a scale-free small-world topology and an ENR-induced resilience to random failures. ENR enhanced large-scale spatiotemporal firing patterns, which facilitated efficient pattern separation and boosted the information encoded in the firing phases of slow oscillatory rhythms. Given that essentially all electrophysiological studies on network behaviors have been done on animals housed in stimulus-poor conditions, our SD mice showed the expected normal functionality. The literature consequently underestimates the extent of spontaneous network activity and connectivity under truly physiological conditions. Our results pave the way to unveil fundamental mechanisms of experience-dependent enhancement in the hippocampal network underlying high brain functions and provide markers for large-scale network remodeling and metaplasticity.

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“…A possible method to improve the brain reserve, other than directly recommending training or learning, would be to encourage behaviour change for new initiatives. For instance, diversity of daily activities is associated with greater hippocampal volume [ 22 ]. This result supports the importance of new initiatives for brain reserve.…”

Section: Introductionmentioning

confidence: 99%

Altered Grey Matter-Brain Healthcare Quotient: Interventions of Olfactory Training and Learning of Neuroplasticity

Watanabe

Yamakawa

Kokubun

2023

Life

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Recent studies revealed that grey matter (GM) changes due to various training and learning experiences, using magnetic resonance imaging. In this study, we investigate the effect of psychological characteristics and attitudes toward training and learning on GM changes. Ninety participants were recruited and distributed into three groups: an olfactory training group that underwent 40 olfactory training sessions designed for odour classification tasks, a group classified for learning of neuroplasticity and brain healthcare using a TED Talk video and 28 daily brain healthcare messages, and a control group. Further, we assessed psychological characteristics, such as curiosity and personal growth initiatives. In the olfactory training group, we conducted a questionnaire survey on olfactory training regarding their interests and sense of accomplishment. In the olfactory training group, the GM change was significantly correlated with the sense of achievement and interest in training. The learning of neuroplasticity and brain healthcare group showed a significantly smaller 2-month GM decline than did the control group. The Curiosity and Exploration Inventory-II scores were significantly correlated with GM changes in both intervention groups only. In conclusion, our result suggested that training or learning with a sense of accomplishment, interest, and curiosity would lead to greater GM changes.

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Diversity of daily activities is associated with greater hippocampal volume

Cited by 23 publications

References 57 publications

Daily activity diversity and daily working memory in community-dwelling older adults.

Daily activity diversity and daily working memory in community-dwelling older adults.

Rich Experience Boosts Functional Connectome and High-Dimensional Coding in Hippocampal Network

Altered Grey Matter-Brain Healthcare Quotient: Interventions of Olfactory Training and Learning of Neuroplasticity

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