Diversity of endophytic fungi from the leaves of
            <i>Vaccinium dunalianum</i>

Fan, Miaomiao; Chen, Xiaoxue; Luo, Xiao‐Dong; Zhang, He; Liu, Yun; Zhang, Yingjun; Wu, Jianrong; Zhao, Chang-Lin; Zhao, Ping

doi:10.1111/lam.13345

Cited by 21 publications

(14 citation statements)

References 36 publications

(60 reference statements)

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“…In the process of cell apoptosis, the membrane is intact, does not release harmful chemical transmitters, and has no negative effect on surrounding cells. [16] Apoptosis is an important event targeted by anticancer drugs. [15] Therefore, we explored whether the growth inhibitory effect of L-OHP is related to cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways

Li¹,

Wang²,

Tian³

et al. 2021

Med. Res.

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Oxaliplatin (L-OHP) is a new platinum anticancer drug, which is used for the treatment of metastatic colorectal cancer or the adjuvant treatment of stage III colon cancer. T-cell acute lymphoblastic leukemias (T-ALLs) are invasive thymocytic malignant tumors with poor prognosis. The purpose of this study was to evaluate the cytotoxic effect of L-OHP on human T-ALL cell lines MOLT-4, Jurkat, CCRF-CEM, and CEM/C1 cells. The CCK-8 method results showed that L-OHP significantly inhibited T-ALL cells proliferation. The inhibition of these T-ALL cells prolife by L-OHP seems to be related to the induction of cell cycle arrest. The effect of L-OHP on the cell cycle distribution of T-ALL cells varies with cell types. As to cells apoptosis, Annexin V/Propidium iodide assay disclosed that L-OHP prominently induced T-ALL cells apoptosis by activating the pathways of mitochondrial biogenesis and is more sensitive to MOLT-4 cells. Western blot analysis showed that L-OHP treatment could promote apoptosis through down-regulated Bcl-2 protein level, up-regulated Bax and caspase-9 proteins levels and cell cycle arrest by inhibiting the PI3K/Akt signaling pathway in MOLT-4 cells. Our results indicate that L-OHP, as a new type of platinum anticancer drug, may attract more attention in the future treatment of T-ALL.

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Section: Discussionmentioning

confidence: 99%

Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways

Li¹,

Wang²,

Tian³

et al. 2021

Med. Res.

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“…has been identified as a major endophytic bacteria frequently isolated from medicinal plants [52][53][54]. The biological compounds produced by P. aeruginosa, as identified by Nxumalo and colleagues, included xanthoxylin, trans-2-decenoic acid, [1,2,4] oxadiazole, 5-benzyl-(thiophen-2-yl), dodecenoic acid, 3-nonynoic, pyrrolo [1,2-a] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl), pentadecanoic acid, and diisooctyl phthalate, which are recognized for antimicrobial activity while cis-9-Octadecenoic acid, 2-dodecenoic acid and 9-octadecenamide possess antioxidant properties [51]. Other bacteria species that have been identified as contributing to specialized metabolites in plants are Bacillus amyloliquefaciens [55] and Bacillus cereus [56] (Table 1).…”

Section: Bacteriamentioning

confidence: 99%

“…Generally, endophytes play an important role in suppressing biotic and abiotic stresses and activating defense mechanisms in plants, thereby contributing to growth and development [2,3]. Due to their unique nature, endophytes have been isolated from different plant parts, such as leaves [4], stems [5], roots [5], flowers [6], seeds [7] and fruits [8]. Different metabolites are found in living organisms, with a greater percentage found in plants; however, microbes are also a peculiar source of over 20,000 compounds that biologically and actively interfere with plant's behavior and the survival of other living organisms [9].…”

Section: Introductionmentioning

confidence: 99%

Production and Functionalities of Specialized Metabolites from Different Organic Sources

et al. 2022

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Medicinal plants are rich sources of specialized metabolites that are of great importance to plants, animals, and humans. The usefulness of active biological compounds cuts across different fields, such as agriculture, forestry, food processing and packaging, biofuels, biocatalysts, and environmental remediation. In recent years, research has shifted toward the use of microbes, especially endophytes (bacteria, fungi, and viruses), and the combination of these organisms with other alternatives to optimize the production and regulation of these compounds. This review reinforces the production of specialized metabolites, especially by plants and microorganisms, and the effectiveness of microorganisms in increasing the production/concentration of these compounds in plants. The study also highlights the functions of these compounds in plants and their applications in various fields. New research areas that should be explored to produce and regulate these compounds, especially in plants and microbes, have been identified. Methods involving molecular studies are yet to be fully explored, and next-generation sequencing possesses an interesting and reliable approach.

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“…This study adopted culture-dependent methods, in accordance with previous endophyte studies in coastal terrain [15,16] or other environments [17][18][19][20]. The samples were quickly transported at 4 • C to the laboratory.…”

Section: Isolation Of Endophytic Fungimentioning

confidence: 99%

Endophytic Fungi of Emersed Halophytes in River Deltas and Tidal Flats of the Korean Ramsar Wetlands

Park

Hong

You

et al. 2021

JMSE

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This study aimed to obtain information on the diversity and distribution of the endophytic fungi in Ramsar wetlands. Vast salt marshes in Suncheon Bay, Korea, are formed by two types of ecotones (tidal flats and deltas) that are supported by the emersed halophytes Phragmites australis and Suaeda japonica. Overall, 324 endophytes were isolated from P. australis (six sampling points in the delta and five in the tidal flats) and S. japonica (six in tidal flats). Margalef’s, Menhinick’s, Shannon’s, and Simpson’s diversity indices significantly varied among the ecotones. In particular, higher variance in diversity value and unevenness was observed in the delta marsh compared with the tidal flat marsh. Further, morphological diversity in the delta salt marsh was 1.8 times higher than that of the tidal flat. Comprising several dominant genera (Aspergillus, Cladosporium, and Penicillium), Epicoccum, Paraconiothyrium, Septoriella, and Talaromyces were widely distributed regardless of the aquatic conditions or halophyte species. This study highlights the distinct distribution and diversity of marine endophytes in various ecotones that can physically protect the coastal areas. This data is of much value to secure a national culture collection for future restoration of the coastal wetlands and their ecosystems.

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Diversity of endophytic fungi from the leaves of Vaccinium dunalianum

Cited by 21 publications

References 36 publications

Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways

Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways

Production and Functionalities of Specialized Metabolites from Different Organic Sources

Endophytic Fungi of Emersed Halophytes in River Deltas and Tidal Flats of the Korean Ramsar Wetlands

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