Diversity of high risk human papilloma viruses in women treated with antiretroviral and in healthy controls and discordance with cervical dysplasia in the South of Benin

Capo-chichi, Callinice D.; Aguida, Blanche; Chabi, Nicodème W.; Acapko-Ezin, Jocelyn; Sossah-Hiffo, Jonas; Agossou, Vidéhouénou K.; Anagbla, Toussain; Zannou, Marcel; Houngbe, Fabien; Sanni, Ambaliou

doi:10.1186/s13027-016-0090-9

Cited by 5 publications

(13 citation statements)

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“…The included studies comprise of review articles which made the bulk of the articles with 77.7% (7/9) [90][91][92][93][94][95][96] and (1/9) transversal case control study [97] and (1/9) quantitative study [98] and each contributed 11.1% respectively.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The studies were done and reviewed from different study settings. About 11.1% (1/9) study generalized about SSA with no specific country mentioned [90], 44% (4/9) reported about Uganda [91,92,95,96], 33% (3/9) South Africa (SA) [93,95,96], 22% (2/9) Senegal [94,96], (1/9) Zambia [93], (1/9) Nigeria [98], and (1/9) Benin [97], and each contributed 11% respectively. Among the included studies, only three were conducted in an urban setting; those of the rest of the studies were not mentioned.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The nine included studies showed evidence of cervical cancer among HIV-infected women and distribution of HPV infection and cervical abnormalities among HIVpositive individuals [90][91][92][93][94][95][96][97][98]. Five studies generalized about HIV and anal cancer [92-94, 96, 98]; only one reported about HIV and penile cancer [93].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…All included studies predominantly reported on women, followed by men and man having sex with man (MSM), except for one which generalized on children and adolescents [90]. The age of the population was not included in most studies, and only one study focused on women of 20 to 60 years old with an average age of 38 years [97]. The total number of participants from all the included studies was 16,351.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…From the included ten studies, two primary studies underwent methodological quality assessment using the appropriate section of the Mixed Methods Appraisal Tool (MMAT)-Version 201 1 [25]. Both studies scored 100% [97,98] (Additional file 3: Table S3). The remaining eight included studies were not appraised for quality because they were not primary studies.…”

Section: Quality Of Evidence From Included Primary Studiesmentioning

confidence: 99%

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The interplay of HIV and human papillomavirus-related cancers in sub-Saharan Africa: scoping review

et al. 2020

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Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Quality Of Evidence From Included Primary Studiesmentioning

confidence: 99%

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The interplay of HIV and human papillomavirus-related cancers in sub-Saharan Africa: scoping review

et al. 2020

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Associations between highly active antiretroviral therapy and the presence of HPV, premalignant and malignant cervical lesions in sub-Saharan Africa, a systematic review: current evidence and directions for future research

et al. 2017

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ObjectivesIn sub-Saharan Africa, substantial international funding along with evidence-based clinical practice have resulted in an unparalleled scale-up of access to antiretroviral treatment at a higher CD4 count. The role and timing of highly active antiretroviral therapy (HAART) in mediating cervical disease remains unclear. The aim of this article is to systematically review all evidence pertaining to Africa and identify research gaps regarding the epidemiological association between HAART use and the presence of premalignant/malignant cervical lesions.MethodFive databases were searched until January 2017 to retrieve relevant literature from sub-Saharan Africa. Publications were included if they addressed prevalence, incidence or clearance of human papillomavirus (HPV) infection in women undergoing HAART as well as cytological or histological neoplastic abnormalities.Results22 studies were included, of which seven were prospective studies. Women receiving HAART are less likely to develop squamous intraepithelial lesions (SILs). There is evidence that duration of HAART along with the CD4 count may reduce the prevalence of high-risk HPV (HR-HPV), suggesting that without HAART, severe immunosuppression increases the risk of becoming or remaining infected with HR-HPV. Furthermore, according to existent literature, the CD4 count, rather than HAART coverage or its duration, plays a central role in the prevalence of cervical intraepithelial neoplasia (CIN) 2 and CIN 3.ConclusionOur findings suggest a positive impact of HAART duration, in conjunction and interaction with CD4 count, on reducing the prevalence of HR-HPV. The greatest treatment effect might be seen among women starting at the lowest CD4 count, which may have a more instrumental role in cervical oncogenesis than either HAART use or the treatment duration on the prevalence of CIN 2 and CIN 3. There is still insufficient evidence to show a clear association between HAART coverage and the incidence of invasive cervical cancer. Enhanced surveillance on the impact of HAART treatment is crucial.

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Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review

et al. 2019

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Background Human papilloma virus (HPV) associated cervical cancer remains a global concern particular, in Sub-Saharan Africa (SSA) where the impact is felt most. Evidence show that many other cancers such as vaginal, anal, oropharyngeal, penile are because of persistent infection with HPV especially, high-risk types. Aim We mapped evidence on the incidence, prevalence, mortality, and the trends of human papillomavirus-related cancers in SSA. Methods A comprehensive literature search was conducted from several databases including PubMed, Google scholar, Science Direct, and CINAHL and MEDLINE via EBSCOhost as well as World Health Organization website for grey literature. Studies reporting HPV-related cancers in SSA outcomes including prevalence, incidence, mortality, and trends were included in this study. The risk of bias of the included studies were assessed using the mixed methods appraisal tool version 2011. We employed PRISMA (preferred reporting items for systematic reviews and meta-analyses) to report the search results. Thematic analysis used to reveal the emerging themes from the included studies. Results Seventy-four (74) studies were retrieved at full article screening, eight of them (six reviews, and two quantitative study) were eligible for data extraction. The degree of agreement between the two independent reviewers following full article screening, was 86.49% agreement versus 64.57% likely by chance which constituted moderate to significant agreement (Kappa statistic = 0.62, p -value< 0.05). Of the eight included studies, four (50%) studies generalized about SSA with no country of interest; two (25%) studies were conducted in Nigeria; one (12.5%) reported about Uganda, Zambia, Guinea, Malawi Tanzania, Mali, Mozambique, Zimbabwe; and one (12.5%) reported about Ethiopia, Senegal, Zimbabwe and Uganda. These eight included studies reported evidence on more than one outcome of interest. Four studies reported about the prevalence of HPV-related cancers, seven studies reported about the incidence, four studies reported about mortality, and four studies reported about the trends of HPV-related cancers. Conclusion This study observation highlighted a gap of knowledge regarding the epidemiological data on the recent HPV prevalence in SSA, which will have a potential impact in determining the distribution of HPV on different body sites (cervix, penis, vagina, vulva, anus and oropharynx). Ongoing research projects are recommended in SSA to enhance the value of HPV, and HPV-associated cancers epidemiological data to inform strategies or/and policies on prevention, diagnosis, and treatment of HPV-related conditions.

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Diversity of high risk human papilloma viruses in women treated with antiretroviral and in healthy controls and discordance with cervical dysplasia in the South of Benin

Cited by 5 publications

References 20 publications

The interplay of HIV and human papillomavirus-related cancers in sub-Saharan Africa: scoping review

The interplay of HIV and human papillomavirus-related cancers in sub-Saharan Africa: scoping review

Associations between highly active antiretroviral therapy and the presence of HPV, premalignant and malignant cervical lesions in sub-Saharan Africa, a systematic review: current evidence and directions for future research

Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review

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