Diversity of Human Immunodeficiency Virus Type 1 Subtype A and CRF03_AB Protease in Eastern Europe: Selection of the V77I Variant and Its Rapid Spread in Injecting Drug User Populations

Roudinskii, N. I.; Sukhanova, Anna L.; Kazennova, Elena; Weber, Jonathan; Pokrovsky, Vadim; Mikhailovich, Vladimir; Bobkov, Aleksei

doi:10.1128/jvi.78.20.11276-11287.2004

Cited by 30 publications

(18 citation statements)

References 43 publications

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“…The rapid expansion of CRF63_02A1 is reminiscent of that reported for other HIV-1 genetic forms in established epidemics, 33,34 supporting the need for continued molecular epidemiological surveillance of HIV-1. Its propagation to distant areas of Russia and to Kazakhstan indicates that CRF63_02A1 should be taken into consideration in the design of vaccines adapted to HIV-1 strains circulating in Russia and other FSU countries, whose HIV-1 epidemics are becoming increasingly complex by the introduction of new genetic forms, phylogenetic diversification within the established strains, 10,[35][36][37] and recombination between cocirculating variants, with the generation of new circulating recombinant forms (CRFs). 17 Sequences were deposited in GenBank under accession numbers KJ197185-KJ197224.…”

Section: Crf63_02a1 Phylogeny and Phylodynamics 913mentioning

confidence: 99%

Short Communication: Molecular Epidemiology, Phylogeny, and Phylodynamics of CRF63_02A1, a Recently Originated HIV-1 Circulating Recombinant Form Spreading in Siberia

Shcherbakova

Shalamova²,

Delgado³

et al. 2014

AIDS Research and Human Retroviruses

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The HIV-1 epidemic in Russia is dominated by the former Soviet Union subtype A (A FSU ) variant, but other genetic forms are circulating in the country. One is the recently described CRF63_02A1, derived from recombination between a CRF02_AG variant circulating in Central Asia and A FSU , which has spread in the Novosibirsk region, Siberia. Here we phylogenetically analyze pol and env segments from 24 HIV-1 samples from the Novosibirsk region collected in 2013, with characterization of three new near full-length genome CRF63_02A1 sequences, and estimate the time of the most recent common ancestor (tMRCA) and the demographic growth of CRF63_02A1 using a Bayesian method. The analyses revealed that CRF63_02A1 is highly predominant in the Novosibirsk region (81.2% in pol sequences) and is transmitted both among injecting drug users and by heterosexual contact. Similarity searches with database sequences combined with phylogenetic analyses show that CRF63_02A1 is circulating in East Kazakhstan and the Eastern area of Russia bordering China. The analyses of near full-length genome sequences show that its mosaic structure is more complex than reported, with 18 breakpoints. The tMRCA of CRF63_02A1 was estimated around 2006, with exponential growth in 2008-2009 and subsequent stabilization. These results provide new insights into the molecular epidemiology, phylogeny, and phylodynamics of CRF63_02A1.

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Section: Crf63_02a1 Phylogeny and Phylodynamics 913mentioning

confidence: 99%

Short Communication: Molecular Epidemiology, Phylogeny, and Phylodynamics of CRF63_02A1, a Recently Originated HIV-1 Circulating Recombinant Form Spreading in Siberia

Shcherbakova

Shalamova²,

Delgado³

et al. 2014

AIDS Research and Human Retroviruses

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“…K20R, M36I, H69KQ) (Table 4) (Grossman et al, 2001;Holguin et al, 2004). However, these genotypic changes by themselves do not consistently confer decreased susceptibility to PIs when viral strains are subject to phenotypic testing (Descamps et al, 2005;Grossman et al, 2004;Ly et al, 2005;Maljkovic et al, 2003;Nkengafac et al, 2007;Palma et al, 2007;Paraskevis et al, 2005;Roudinskii et al, 2004;Vazquez de Parga et al, 2005;Wensing et al, 2005). Consistent with this, most observational studies performed in vitro and in vivo suggest that the currently available PR and RT inhibitors are as active against non-B subtype viruses as they are against subtype B viruses (Santos and Soares, 2010).…”

Section: Impact Of Hiv-1 Diversity In Drug Resistancementioning

confidence: 85%

HIV-1 Diversity and Its Implications in Diagnosis, Transmission, Disease Progression, and Antiretroviral Therapy

Bártolo¹,

Taveira²

2012

Genetic Diversity in Microorganisms

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“…117 In order to make easier the vaccine design and evaluation, several programs for typing the HIV-1 isolates have been implemented mainly for countries suitable as sites for conducting the phase III vaccine efficacy trials. 35 For these proposals, the employed techniques include serotyping, 137 heteroduplex mobility assay (HMA), 14,30,31 RT-polymerase chain reaction (RT-PCR)-gag fingerprinting 50,73,85,118,145 and lately DNA microarray assays have been introduced for this purpose. 124 The HIV subtyping has been an important molecular tool for monitoring the geographic changes in worldwide AIDS epidemic.…”

Section: Genomic Variabilitymentioning

confidence: 99%

Worldwide molecular epidemiology of HIV

Requejo

2006

Rev. Saúde Pública

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Human immunodeficiency virus (HIV) is the worldwide disseminated causative agent of acquired immunodeficiency syndrome (AIDS). HIV is a member of the Lentivirus genus of Retroviridae family and is grouped in two types named HIV-1 and HIV-2. These viruses have a notable ability to mutate and adapt to the new conditions of human environment. A large incidence of errors at the transcriptional level results in changes on the genetic bases during the reproductive cycle. The elevated genomic variability of HIV has carried important implications for the diagnosis, treatment and prevention as well as epidemiologic investigations. The present review describes important definitions and geographical distribution of subtypes, circulating recombinant forms and other genomic variations of HIV. The present study aimed at leading students of Biomedical Sciences and public health laboratory staff guidance to general and specific knowledge about the genomic variability of the HIV.

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Diversity of Human Immunodeficiency Virus Type 1 Subtype A and CRF03_AB Protease in Eastern Europe: Selection of the V77I Variant and Its Rapid Spread in Injecting Drug User Populations

Cited by 30 publications

References 43 publications

Short Communication: Molecular Epidemiology, Phylogeny, and Phylodynamics of CRF63_02A1, a Recently Originated HIV-1 Circulating Recombinant Form Spreading in Siberia

Short Communication: Molecular Epidemiology, Phylogeny, and Phylodynamics of CRF63_02A1, a Recently Originated HIV-1 Circulating Recombinant Form Spreading in Siberia

HIV-1 Diversity and Its Implications in Diagnosis, Transmission, Disease Progression, and Antiretroviral Therapy

Worldwide molecular epidemiology of HIV

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