Diversity of killer cell immunoglobulin like receptor genes in the Mongolian population

Novel KIR genotypes and gene copy number variations in northeastern Thais

“…Genotypes 1, 2, 3, 4, 5, 7 and 8 were commonly found (> 5% frequency) as seen in previous studies of the Thai population. To compare KIR genotype with other populations, the genotype frequencies of Asians (Chinese Han, Mongolian and north Indian), Europeans (Italian and English) and Amerindian (north Brazilian) were included, showing that genotype IDs 1 and 2 were the most common genotypes (> 10% frequency) in Amerindian, Europeans and most Asians (NETs, Thais, Chinese Han and Mongolian), whereas other genotypes varied among populations. Individually, the frequencies of all KIR genotypes in north Indians were < 10%, with the most common genotype found at 9·3%.…”

KIR genotype and haplotype repertoire in Kuwaiti healthy donors, hematopoietic cell transplant recipients and healthy family members

“…Sugioka et al observed in a study of a Brazilian population that specific inhibitory and activating genes had different frequencies in healthy donor family members compared to patients and suggested that susceptibility to leukemia could be influenced partly by KIR receptors. 20 The aim of this study is to (1) characterize KIR haplotypes in Kuwaiti subjects by haplotype segregation in families and compare haplotype frequencies with published data from other populations, 36,46 (2) compare the frequency of the KIR genes among a cohort of HCT recipients and healthy Kuwaiti volunteer donors from the Kuwaiti unrelated donor registry (3) compare the frequency of the KIR genes in healthy Kuwaiti volunteer donors to published frequencies in other populations, 36,[47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] and (4) investigate the generalizability of the observed differences in KIR gene carrier frequency among patients with hematological malignancies and healthy donors in the Brazilian population were generalizable to other populations such as Kuwaitis. 20 Findings of this study may guide future research investigating the importance of the KIR genes and their associations with particular diseases and potentially KIR based HCT donor selection strategies.…”