Now sickle cell disease (SCD) is an important health issue in many countries. India has been ranked as the second worst affected country in terms of predicted SCD births. SCD is an abnormal of the hereditary haematological disorder. The study was including 57 number of SCD patients which belong to the tribal region. These patients experienced with several symptoms like fever, loss of appetite, abdominal distension, myalgia, pain in legs, jaundice and black stool. Female individuals were more prevalent to SCD in compare to male. The SCD patients with an average age of 12.99 (±11.66) years. There was found significant difference in between the male individuals at (p<0.01). In these patients the concentration of haemoglobin, iron and ferritin also varies. In ABO blood group O blood group more prevalent than other blood group. SCD often causes complications on many organs. As the prevalence is more common in children, this will affect the socioeconomic status of a nation. This becomes a major challenge for healthcare professionals. Proper diagnosis and awareness for SCD in susceptible region is necessary for the better management and control of this disease. A well-designed epidemiological analysis will be necessary for better treatment and prevention of this disease.