Diversity of T H cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania

Wang, Xiangdong; Zhang, Nan; Bo, Mingyu; Holtappels, Gabriële; Zheng, Ming; Lou, Hongfei; Wang, Hong; Zhang, Luo; Bachert, Claus

doi:10.1016/j.jaci.2016.05.041

Cited by 487 publications

(578 citation statements)

References 31 publications

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“…In contrast, CRSsNP has more diverse immunological endotypes that remain poorly defined. 83 In CRSwNP, eosinophilic inflammation is present with amplification of IL-4-, IL-5-and IL-13-driven pathways. Recent work has highlighted type II ILC-infiltrated polyp tissue with Th2-skewed cells expressing IL-25R and IL-33R.…”

Section: Ch Ronic R Hin Osin Usitis and Sinon Asal Remodellingmentioning

confidence: 99%

Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited

Samitas

Carter

Kariyawasam

et al. 2017

Allergy

210

156

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Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co-exist. The one airway model proposes that disease mechanisms occurring in the upper airway may mirror lower airway events. Airway remodelling is the term used to describe tissue structural changes that occur in a disease setting and reflect the dynamic process of tissue restructuring during wound repair. Remodelling has been long identified in the lower airways in asthma and is characterized by epithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, airway smooth muscle hyperplasia and increased angiogenesis. The concept of upper airway remodelling has only recently been introduced, and data so far are limited and often conflicting, an indication that more detailed studies are needed. Whilst remodelling changes in AR are limited, CRS phenotypes demonstrate epithelial hyperplasia, increased matrix deposition and degradation along with accumulation of plasma proteins. Despite extensive research over the past years, the precise cellular and molecular mechanisms involved in airway remodelling remain incompletely defined. This review describes our current rather limited understanding of airway remodelling processes in AR, CRS and asthma and presents mechanisms both shared and distinct between the upper and lower airways. Delineation of shared and disease-specific pathogenic mechanisms of remodelling between the sinonasal system and the lung may guide the rational design of more effective therapeutic strategies targeting upper and lower airways concomitantly and improving the health of individuals with inflammatory airway diseases.

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Section: Ch Ronic R Hin Osin Usitis and Sinon Asal Remodellingmentioning

confidence: 99%

Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited

Samitas

Carter

Kariyawasam

et al. 2017

Allergy

210

156

View full text Add to dashboard Cite

show abstract

“…In Western populations, CRSwNP is near uniformly an eosinophilic condition, whereas CRSsNP is more heterogeneous. 4,5 In the United States, there currently are no data on the relative frequency of endoscopic sinus surgeries (ESS) performed for CRSwNP versus CRSsNP. Previous studies on CRSwNP demonstrate increased rates of revision surgery but also greater improvements after sinus surgery compared with patients with CRSsNP.…”

Section: Hronic Rhinosinusitis (Crs) Is Characterized By Mucosal Inmentioning

confidence: 99%

How Often is Sinus Surgery Performed for Chronic Rhinosinusitis with versus without Nasal Polyps?

Ference

Suh

Tan

et al. 2018

Am J Rhinol�Allergy

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“…Discrepancies between the studies could be due to different sampling methods or different presentations of the disease; studies found significant variation in cytokine profiles between different countries of origin or ethnicities in CRS. 55 Therefore, similar to AR, additional investigation is needed, focused more specifically on Treg function and less on expression of markers to determine their presence or absence.…”

Section: Alterations In Treg Numbers and Functions In Ar And Crswnpmentioning

confidence: 99%

The Role of Regulatory T Cells in the Regulation of Upper Airway Inflammation

Palmer

Mulligan

Smith

et al. 2017

Am J Rhinol�Allergy

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Diversity of T H cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania

Abstract: T cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.

Cited by 487 publications

References 31 publications

Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited

Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited

How Often is Sinus Surgery Performed for Chronic Rhinosinusitis with versus without Nasal Polyps?

The Role of Regulatory T Cells in the Regulation of Upper Airway Inflammation

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