Diversity-oriented synthesis of 1H-1,2,3-triazole tethered pyrazolo[5,1-b]quinazoline hybrids as antimicrobial agents

Chudasama, Dipakkumar D.; Patel, Manan S.; Parekh, Jaydeepkumar N.; Patel, Harsh C.; Ram, Kesur R.

doi:10.1007/s11030-023-10721-8

Cited by 4 publications

(1 citation statement)

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“…1,2,3-Triazoles are pervasive parts in various drug-like molecules, prized for their excellent biocompatibility and notable stability. , They possess a wide range of biological profiles counting antimitosis, anticancer, antibacterial, antivirus, and antituberculosis activities (Figure ). − Moreover, 1,2,3-triazoles have been found in photostabilizers, agrochemicals, fluorescent sensors, dyes, and corrosion inhibitors as crucial structural components. − Recently, Maleki et al prepared the Fe 3 O 4 @Creatine@Cu catalyst which works well as a catalyst for the synthesis of 1,2,3-triazoles . Considering their immense synthetic and biological importance, much attention has been paid to their synthesis in the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Meglumine Encapsulated CuI: A Green Heterogeneous Catalyst Derived from Low Value Biomass Meglumine to Access 1,2,3-Triazole Scaffolds

Patel,

Parekh,

Chudasama

et al. 2024

ACS Sustainable Resour. Manage.

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In current state of the art, we report a solitary pot green tactic for the synthesis of task-specific CuI nanoparticles (NPs) encapsulated by ecohealthy low value biomass (LVBM) meglumine. The synthesized meglumine encapsulated CuI NPs (Meg-Cu) material was characterized by using various analytical tools, and it was found that CuI NPs (with <100 nm size) were encapsulated by meglumine molecules interacting with −NHMe and −OH functionalities of meglumine. Meg-Cu was utilized marvelously as a catalyst for the creation of 1,2,3-triazole scaffolds. The established protocol allowed the synthesis of 1,2,3-triazoles via both two-and three-component routes. Moreover, the protocol was efficiently used for the synthesis of 1,2,3-triazoles initiated from anilines via in-situ generation of aromatic azides. The catalyst was successfully recycled up to three times without a loss of catalytic activity. The structural integrity of the spent catalyst was investigated by FT-IR and TGA analysis. The present protocol embraces features like a short reaction time, wide substrate scope, environment-friendly reaction conditions, and good to excellent yields.

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