Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

Abstract

The venerable Mannich reaction using p-anisidine, aldehyde, and a nucleophile affords a linear α-secondary amine motif. Herein, we report that a slight yet rational modification of the reaction inputs diverts...