Divinyl Ether

Goldschmidt, Samuel; Ravdin, I. S.; Lucké, Balduin; Muller, G. P.; Johnston, C. G.; Ruigh, William L.

doi:10.1001/jama.1934.02750010021005

JAMA

1934

DOI: 10.1001/jama.1934.02750010021005

|View full text |Cite

Divinyl Ether

Samuel Goldschmidt¹,

I. S. Ravdin²,

Balduin Lucké³

et al.

Abstract: Operation, and the ineffectiveness of roentgen irradia¬ tion on the remaining tissue emphasize the therapeutic importance of removing the entire gland at the time of the first operation. Ample confirmation for this con¬ clusion was obtained by our subsequent experience in some fifty cases of angina pectoris or congestive failure, in all of which the basal metabolic rate remained low after total ablation of the thyroid gland, and in practi¬ cally all of which the clinical improvement has been conspicuous.330 Br… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1934

1942

Publication Types

Select...

Article6

Relationship

Self Cite1

Independent5

Authors

Journals

Cited by 25 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this paper is described the method used for the determination of divinyl ether in the blood of anesthetized dogs and man. Some of the results obtained have already been published in papers (3,17,18,19) which include both experimental and clinical studies of divinyl ether. Root has also used the method described for ethyl ether determinations in dogs (12).…”

mentioning

confidence: 99%

Analysis of Divinyl Ether in Blood

Ruigh¹

1942

Ind. Eng. Chem. Anal. Ed.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Analysis of Divinyl Ether in Blood

Ruigh¹

1942

Ind. Eng. Chem. Anal. Ed.

View full text Add to dashboard Cite

Convulsions During General Anesthesia

Lorhan¹

1942

Arch Surg

View full text Add to dashboard Cite

The Rôle of Pharmacology in the Development of Ideal Anesthesia

Leake¹

1934

JAMA

View full text Add to dashboard Cite

Since no drug is quite ideal for its purpose, stimulus exists for commercial as well as scientific efforts to develop better drugs than any now in use for a particular clinical effect. Scientifically, such an effort is usually based on some phase of what may be called biochemorphology,1 i. e., the relation between chemical constitution and biologic action. A chemist, after considering, for instance, the biochemorphic aspects of hypnotics, synthesizes a new substance, which is found to have hypnotic action. Commercially there now comes a strong temptation to introduce the new agent clinically without furnishing physicians sufficient comparative scientific data to enable them to judge whether or not it has advantages recommending it over hypnotics already in common use. One would be naive indeed to believe that the pharmaceutic concern developing the new hypnotic could give unbiased judgment on this point. But it is thus that the hopeful good humor of physicians is too often exploited with unnecessary harm or expense to their patients. Four years ago, before the Portland session of the American Medical Association, I tried to outline in a general way the position of pharmacology in the appraisal of drugs suggested for general use in medi¬ cine.2 It was pointed out that clinical trial of a new chemical should be made only after disinterested phar¬ macologie study has estimated in comparison with related agents (a) its possible^'karmful effects, (b) its type or mode of action and (c) me reasonableness of its replacing existing drugs in application to human beings. It was further indicated that the new agent should not be offered for general use to physicians until favorable reports on it had been published from reliable chemical, pharmacologie and clinical sources. Pharmacologie data are more readily accepted from university laboratories than from commercial labora-tories, and clinical information is usually relied on when it comes from a university or independent research hospital. Physicians might place greater con¬ fidence in commercial concerns if they would cooperate with such institutions rather than supplant them with their own. While it is to be hoped that Sir Henry Dale's pious good wishes for American pharmaceutic houses may come true,3 past experience indicates that American physicians must support more fully the judg¬ ment of the Council on Pharmacy and Chemistry of the American Medical Association and insist more strongly on adequate and reliable pharmacologie and clinical data in connection with new drugs if they are to free themselves from exploitation. One need only think of the current situation in local anesthesia and preanesthetic medication to realize the significance of these remarks. It is yet to be satisfactorily demon¬ strated, not only pharmacologically and clinically but also from the standpoint of expense, that for infiltra¬ tion and spinal anesthesia or nerve block a better local anesthetic is available than procaine, that any of the many modifications of barbital surpass it for ordinary p...

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Divinyl Ether

Cited by 25 publications

References 1 publication

Analysis of Divinyl Ether in Blood

Analysis of Divinyl Ether in Blood

Convulsions During General Anesthesia

The Rôle of Pharmacology in the Development of Ideal Anesthesia

Contact Info

Product

Resources

About