Dixyrazine premedication for cataract surgery. A comparison with diazepam

Abstract

Given as a peroral premedicant for geriatric patients having cataract surgery under regional block, a butyrophenone neuroleptic melperon (15-30 mg, n = 50) ranked equally with diazepam (4-10 mg, n = 50), assessed using a qualitative subjective estimation of the patients' anxiety. The patients treated with melperon needed significantly fewer supplementations with intravenous drugs, to withstand the surgery, compared to those medicated with diazepam. Melperon is a compatible alternative, but its possible propensity to cause occasional arterial hypotension must be noticed.

Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

“…Due to its capacity to block antidopaminergic, histamine and acetycholine receptors and thanks to its low adrenergic receptor-blocking activity and the small degree of autonomic vasomotor regulation disturbances involved, dixyrazine is attractive for clinical use (4,5). Due to its capacity to block antidopaminergic, histamine and acetycholine receptors and thanks to its low adrenergic receptor-blocking activity and the small degree of autonomic vasomotor regulation disturbances involved, dixyrazine is attractive for clinical use (4,5).…”

“…Dixyrazine, a phenothiazine derivative, is another neuroleptic drug with potent antiemetic properties. Due to its capacity to block antidopaminergic, histamine and acetycholine receptors and thanks to its low adrenergic receptor-blocking activity and the small degree of autonomic vasomotor regulation disturbances involved, dixyrazine is attractive for clinical use (4,5). Clinical data using dixyrazine as a postoperative antiemetic drug are sparse (6), and the clinical experience is mainly limited to chemotherapy (7,8) and pediatric patients (4,9,10).…”