Amateurs committed to self-production (i.e. DIY) are reshaping the relationship between production and consumption, leading to a 'new DIY age' (Hoftijzer 2009). The spreading of this trend suggests scenarios in which non-professional people are, or will be, able to create artefacts supported by innovative technologies, networks and, perhaps, companies with new business models. Easy access for consumers to the production system could lead to inefficient resource use and increased waste, however, and so the sustainability of this trend has been debated. Nonetheless, recent research by Salvia (2013) envisages this contemporary self-production phenomena as a 'window of opportunity' to foster positive environmental and social impact, through activities intended to prolong product lifetimes, e.g. re-using, re-pairing, re-purposing and re-appropriating-collectively named RE-DIY. This chapter addresses the role of design as catalyst for sustainable RE-DIY. Four scenarios portray the possible role of professional designers as educators or facilitators in the relationship with RE-DIY practitioners, at both a global and local scale. On the basis of a review of the current 'state of the art', cases of design-led sustainable initiatives promoting RE-DIY are explored to highlight the potential and feasibility of novel relationships between producers and consumers. Finally, barriers to the evolution of RE-DIY towards sustainable patterns are identified and discussed, and triggers for scaling up this practice on a broader societal level are proposed.