Diyabetik Sıçan Karaciğerinde Pazı Ekstresinin Glikoprotein Bileşikleri ve İleri Oksidasyon Protein Ürün Seviyeleri Üzerindeki Koruyucu Etkisi

Yanardağ, Refiye

doi:10.26650/experimed.2021.879204

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…[56] Previous studies have shown that diabetes leads to increasing levels of glycoprotein components. [57,58] Similar to the outcome of the present study, Gorgun et al [59] showed that Mel reduced the STZinduced effects on plasma SA levels.…”

Section: Discussionsupporting

confidence: 87%

The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes

Ertik

Şener

Yanardağ

2022

J Biochem & Molecular Tox

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In this present study, the duration of melatonin (Mel) administered to diabetic rats was prolonged so as to examine its effects on the biochemical liver parameters of diabetic rats. In the experiment, Male Sprague Dawley rats were divided randomly into five groups; the control, diabetic + Mel, diabetic, diabetic + insulin, and diabetic + Mel + insulin. Diabetes mellitus was induced by administration of a single dose of streptozotocin (60 mg/kg) intraperitoneally and rats were given vehicle as a solvent for Mel every day for 12 weeks. In the diabetic + Mel group, diabetic rats were administered Mel (10 mg/kg/day) for 12 weeks to treat diabetes. The diabetic + insulin group were diabetic rats given insulin (6 U/kg) subcutaneously for 12 weeks. The diabetic + Mel + insulin rats received insulin and Mel at the same dose and time. At the end of the experiment, the animals were decapitated and liver tissues were taken. The protective effect of Mel on liver tissue of diabetic rats was investigated, total antioxidant status, total oxidant status, reactive oxygen species, oxidative stress index, adenosine deaminase, xanthine oxidase, paraoxonase 1, sodium/potassium ATPase, myeloperoxidase, γ-glutamyl transferase, sorbitol dehydrogenase, tumor necrosis factor-alpha, homocysteine, nitric oxide, glucose-6-phosphate dehydrogenase, and glycoprotein levels were determined in liver tissues. Treatment with Mel and/or insulin has been found to have a protective effect on biochemical parameters. The results showed that administration of Mel to diabetic rats prevented the distortion of the studied biochemical parameters of liver tissues.

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Section: Discussionsupporting

confidence: 87%

The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes

Ertik

Şener

Yanardağ

2022

J Biochem & Molecular Tox

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Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats

Alev¹,

Tunalı²,

Üstündağ³

et al. 2023

Food Health

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Valproic acid, one of the most used drugs for epilepsy patients, has some known side effects. Chard extract has many pharmacological activities. The study aims to evaluate whether valproic acid might interfere with oxidative metabolism in gastric tissue and whether chard ameliorates these effects. The Sprague Dawley rats were divided into four groups (n=8); control, chard-given control, valproic acid, and chard-given valproic acid. The aqueous extracts of chard leaves were given 1 h before the administration of valproic acid for 7 days. On the 8th day, the animals were sacrificed under anesthesia and gastric tissues were homogenized. When compared to the control group, valproic acid significantly increased malondialdehyde and catalase activity, while superoxide dismutase activity decreased. Chard administration increased glutathione and, sialic acid levels and decreased malondialdehyde levels and superoxide dismutase activity in the valproic acid group. Based on these findings, since chard increased gastric sialic acid levels, we may suggest that chard may protect gastric mucosa may be through its antioxidant effects.

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Diyabetik Sıçan Karaciğerinde Pazı Ekstresinin Glikoprotein Bileşikleri ve İleri Oksidasyon Protein Ürün Seviyeleri Üzerindeki Koruyucu Etkisi

Cited by 2 publications

References 25 publications

The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes

The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes

Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats

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