2011
DOI: 10.1038/onc.2011.315
|View full text |Cite
|
Sign up to set email alerts
|

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
20
0

Year Published

2011
2011
2018
2018

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 31 publications
(22 citation statements)
references
References 49 publications
2
20
0
Order By: Relevance
“…Knockdown of Apollon increased expression of proapoptotic Bcl-2 family members, enhanced activation of caspase-2, an initiator caspase of the mitochondrial/intrinsic pathway, and even of caspase-8, an initiator caspase of the extrinsic pathway (37). In agreement, Apollon silencing improved melanoma cell death in response not only to cytotoxic drugs and pathway inhibitors that trigger the intrinsic pathway of apoptosis (34-35) but also to soluble or membrane bound TRAIL that activate the extrinsic apoptotic cascade.…”
Section: Discussionmentioning
confidence: 99%
“…Knockdown of Apollon increased expression of proapoptotic Bcl-2 family members, enhanced activation of caspase-2, an initiator caspase of the mitochondrial/intrinsic pathway, and even of caspase-8, an initiator caspase of the extrinsic pathway (37). In agreement, Apollon silencing improved melanoma cell death in response not only to cytotoxic drugs and pathway inhibitors that trigger the intrinsic pathway of apoptosis (34-35) but also to soluble or membrane bound TRAIL that activate the extrinsic apoptotic cascade.…”
Section: Discussionmentioning
confidence: 99%
“…DJ-1 is a multifunctional redox sensitive protein regulating mitochondrial oxidative stress and increases expression levels of SOD1 in an Erk1/2-Elk1 pathway dependent manner,74 and facilitates prosurvival factor Akt, leading to suppression of apoptosis 75. Also, the protein inhibits TRAIL induced apoptosis by blocking Fas associated protein death domain mediated pro-caspase-8 activation 76. Along with parkin and PINK1, DJ-1 has various cellular functions such as regulation of mitochondrial morphology as well as misfolded protein degradation by forming an E3 ligase complex with those proteins 77…”
Section: Hereditary Pdmentioning
confidence: 99%
“…Despite some evidence supporting the role of the death receptor pathway in PD cell death (Boka et al 1994;de la Monte et al 1998;Mogi et al 2000;Hayley et al 2004;Ho et al 2009;Simunovic et al 2009;Fu et al 2011), the mitochondrial pathway may play a major role in triggering apoptosis in PD.…”
Section: Two Roads To Apoptotic Deathmentioning
confidence: 99%