2021
DOI: 10.21203/rs.3.rs-743363/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

dl922-947 Adenovirus and G-Quadruplex Binder Combination Against Breast Cancer and Modulation of Monocyte Activity

Abstract: Background: G-quadruplex (G4) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabilization induced by G4 ligands might potentiate the anticancer activity of agents targeting DNA or inhibiting its repair like oncolytic viruses. This study represents the first approach combining G4 ligands and the adenovirus dl922-947 in MDA-MB-231 and MCF-7 cell li… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 20 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?