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Voskuil, J.H.; Dijk, Martin M. van; Wagenaar, Sjoerd Sc.; Vliet, A. C. M. Van; Timmer, Robin; Hees, P. A. M. van

doi:10.1023/a:1010676715046

Cited by 55 publications

(16 citation statements)

References 7 publications

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“…Follow-up was indicated for all the patients, independent of tumor resection (15,16). In the largest series as yet, specific cases left untreated showed either a stable tumor size or regression of the tumor (9). …”

Section: Discussionmentioning

confidence: 98%

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Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

2014

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Esophageal granular cell tumors (GCTs) are rare and often misdiagnosed. To demonstrate their clinicopathological features, the present study reports 19 cases and reviews the literature. There were 11 female and eight male esophageal GCT patients with a median age of 42.0 years. All the tumors were solitary. The majority of patient indications for endoscopy (89.5%) were non-specific and endoscopic therapy was performed in 17 cases with a relapse in one case after a 12-month follow-up. The endoscopic appearance of esophageal GCT was variable and the majority of tumors (80.0%) were located in the middle and lower esophageal segments. The size of the tumors ranged from 0.4 to 2 cm in diameter and the surface was white-gray, pink or yellow. Nine patients underwent an endoscopic ultrasound exam, eight of which demonstrated hypoechoic echostructures with a smooth margin and intracavity growth features. One case was derived from the muscularis propria layer with an irregular margin and intra- and extra-cavity growth features. The histological features could mimic other tumors and immunohistochemical stains are usually positive for S-100, periodic acid-Schiff, neuron-specific enolase and nestin. Three cases indicated pleomorphism and Ki-67 was locally positive. Esophageal GCTs are rare and endoscopic ultrasound features are variable. Immunohistochemical staining may aid in the diagnosis.

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Section: Discussionmentioning

confidence: 98%

“…Esophageal GCT could occur at any age, but it is more common in 40- to 60-year-old patients (9,10) and in females compared with males (5,10–12). The present study reconfirmed these results.…”

Section: Discussionmentioning

confidence: 99%

Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

2014

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“…Although esophageal GCTs are usually benign lesions, malignant transformation has been reported even in those smaller than 10 mm [4,5]. Moreover, some patients became distressed and desperately sought efficacious resection during follow-up time.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic submucosal dissection of esophageal granular cell tumor

Zhou

et al. 2014

World J Surg Onc

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BackgroundEsophageal granular cell tumor (GCT) is a rare benign tumor with malignant potential. With wide application of endoscopic techniques, the esophageal GCT discovery rate and treatment strategy has changed. This study was to preliminarily evaluate outcomes of endoscopic diagnosis and treatment for esophageal GCT.MethodsFourteen patients (eight men, six women; median age, 48.5 years) with esophageal GCT diagnosed and treated by esophageal endoscopy. Esophagoscopy, endoscopic ultrasound (EUS), and endoscopic submucosal dissection (ESD) techniques were employed in diagnosis and resection.ResultsEsophageal GCTs are tumors which arise from the submucosal layer, and vary in color but with a yellowish color on endoscopy being most common. On EUS, features were homogenous (ten cases) or mildly heterogeneous (four cases) hypoechoic solid pattern originating from the muscularis mucosa (six cases) or submucosal layer (eight cases) of the esophageal wall. Tumors ranged from 4 to 26 mm (mean 12.1 mm). ESD was performed in all patients without complication. Clinical diagnosis was confirmed by pathology and immunohistochemical examination (positive for S-100 and vimentin). The en bloc resection rate was 92.9% (13/14) pathologically. Operation time was 25 to 60 minutes, mean 38.2 ± 10.1 minutes. No recurrence was observed during a mean follow-up of 16.6 ± 12.7 (range, 4 to 40) months.ConclusionsEsophagoscopy and EUS increased the esophageal GCT discovery rate, and its features were summarized. Minimally invasive ESD is feasible and safe for excisional biopsy, providing pathological diagnosis and treatment.

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“…Among the GCTs, two thirds are lesions developing in the lower part of the oesophagus. These are usually asymptomatic [6]. …”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of a rare case of granular cell tumour of the cervical oesophagus.

Piecuch¹,

Wiewióra²,

Latos³

2013

Videosurgery and Other Miniinvasive Techniques

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A female patient was operated upon due to cervical oesophageal stricture induced by a tumour located just below the throat. Local excision of the tumour and reconstruction of the oesophageal wall was performed using the pre-vertebral fascia due to the presence of extensive oesophageal mucosa damage. The patient also required temporary alimentation by the gastrostomy route due to swallowing disturbances. The oesophagram depicted a contrasting airway passage without any evidence of fistula and contrast medium leakage through the oesophageal lumen. Four months after the operation, the patient did not report any issue with oral intake. The postoperative histopathological and immunohistochemical examinations provided evidence of a granular cell tumour (GCT). We believe that local excision of the tumour should always be considered in cases of tumours located close to the throat because it is less invasive than partial resection of a GCT in the oesophagus or oesophagogastrectomy.

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Untitled

Cited by 55 publications

References 7 publications

Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

Endoscopic submucosal dissection of esophageal granular cell tumor

Surgical treatment of a rare case of granular cell tumour of the cervical oesophagus.

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