In modern aviation production, innovative hard-to-machine materials with unique physical and mechanical properties are being used increasingly. When processing such materials, the weakest link in the technological chain of production is the metal-cutting tool. In this paper, to improve the efficiency of the blade cutting of heat-resistant alloys, we propose the use of nanostructured multilayer wear-resistant coatings with subsequent laser processing of the cutting surfaces of the end milling cutters according to various schemes. In this case, an increase in the wear-resistant properties of the cutting edge by 15%–20% is provided due to the formation, at high temperatures, of secondary structures with increased wear resistance and a reduction of the temperature and force loading of contact processes. Methodologically, the work was carried out in several consecutive stages: the first stage was the determination of effective grades of wear-resistant coatings obtained via various installations with their subsequent laser processing during the «SharpMark™ Fiber» installation; at the second stage tribotechnical tests were carried out during the tribometer and adhesion installation; and in the third stage wear-resistant, temperature-force tests were carried out using milling machines in various cutting modes. According to the results of the field tests, the tool durability period was increased by 15%–20%.