DLE Progressing to Squamous Cell Carcinoma: A Case Report

Abstract

A 90 years female diagnosed as a case of Discoid lupus erythematosus (DLE) developed Squamous cell carcinoma from the lesions over a period of 5 years due to treatment gap and late follow up. Diagnosis was based on clinical aspects (erythematous, nodular and scanty bleeding), dermoscopic features and histopathological examination,the absence of systemic involvement and routine laboratory parameters, which registered all within normal range.SCC in a patient with DLE is rare in Nepalese patients. It is every essential to counsel the diagnosed cases of DLE and warn all patients about all the possible outcomes and compliance with medications should be ensured.

Cutaneous squamous cell carcinoma in a disseminated discoid lupus erythematosus lesion

“…4 SCC arising from DLE lesions has worse outcomes in terms of metastasis, recurrence, and death when comparing it to conventional squamous cell cancer of the skin. 5,6 DLE is subdivided into a localized form in which lesions are confined to the face and neck or a disseminated form in which lesions also occur elsewhere on the body. Malignant transformation is a rare complication of this condition.…”